NAGAMATSU Tomohisa

J-GLOBAL         Last updated: Jul 1, 2016 at 13:32
 
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Name
NAGAMATSU Tomohisa
Affiliation
Kumamoto University
Section
School of Pharmacy
Degree
Ph. D.(Australia), Master of Pharm.(Kumamoto University)
Other affiliation
Okayama University

Research Areas

 
 

Academic & Professional Experience

 
 
   
 
Associate Professor, Okayama University Graduate School of Medicine ,Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University
 
1989
 - 
2004
 Associate Professor,Faculty of Pharmaceutical Sciences,Okayama University
 
2004
   
 
- Associate Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University
 
1979
 - 
1981
 Postdoctoral fellow,1979-1981 Jones Hopkins University, Postdoctral Fellow
 
1982
 - 
1989
 Research Associate,1982-1989 Kumamoto University, Research Associate
 

Education

 
 
 - 
1974
Pharmaceutical Chemistry, Graduate School, Division of Pharmaceutical Sciences, Kumamoto University
 
 
 - 
1979
Medical chemistry, Graduate School, Division of Medical Science, (The Australian National University, The John Curtin School of Medical Research)
 

Misc

 
A New, General Synthesis of Pyrazolo[3,4-d]pyrimidine Derivatives.
F. Yoneda and T. Nagamatsu.
Synthesis   (5) 300-301   1973
Transmethylation from Toxoflavins to Nucleophiles.
F. Yoneda and T. Nagamatsu.
Journal of the American Chemical Society   95(17) 5735-5737   1973
Transformation of Toxoflavin into Fervenulin via 1-Demethyltoxoflavin.
F. Yoneda and T. Nagamatsu.
Tetrahedron Letters   (17) 1577-1580   1973
Synthesis and Properties of 6-Benzyl Analogs of Toxoflavin.
F. Yoneda, T. Nagamatsu, and M. Ichiba.
Journal of Heterocyclic Chemistry   11(1) 83-85   1974
Pyrolysis and Photolysis of 6-(Benzylidene-1''-methylhydrazino)-1,3-dimethyluracils. A Method to Convert Aldehydes to Nitriles. A New Synthesis of Pyrazolo[3,4-d]pyrimidines.
F. Yoneda and T. Nagamatsu.
Heterocycles   2(2) 153-158   1974

Books etc

 
Chemistry of Heterocycles - Foundation of the Medical Supplies -
Kagakudojin   2002   ISBN:7598-0905-8
Chemistry of Heterocycles - Foundation of the Medical Supplies - Revised Edition
Kagakudojin   2009   ISBN:9784759809053

Conference Activities & Talks

 
Synthesis, Biological Active Molecular Design, and Molecular Docking Study of 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins
Twelfth Tetrahedron Symposium, Challenge in Organic and Bioorganic Chemistry   2011   
Synthesis of Deazaflavin-Steroid Hybrid Compounds for Biologically Significant Molecules such as Anti-coccidium and Antitumor Agents
23rd International Congress on Heterocyclic Chemistry (ICHC-23)   2011   
SYNTHESIS AND MOLECULAR DOCKING STUDY OF 6,7-DIHYDRO-5H-PYRAZOLO[4,3-E][1,2,4]TRIAZOLO[1,5-C]PYRIMIDIN-5-ONES AS POTENT XO INHIBITORS
4th International Symposium on Advances in Synthetic and Medicinal Chemistry (ASMC 2011)   2011   
Synthesis of pyrimido[4,5-b][1,8]naphthylidine-2,4(3H,10H)-diones and their ring transformation into oxazolo[4,5-b][1,8]naphthyridin-2(4H)-ones aimed molecular design for antitumor activity.
41Th CONGRESS OF HETEROCYCLIC CHEMISTRY   2011   
In Silico Search and Syntheis of Flavin Analogs as Protein Kinase Inhibitors and Antitumor Activities
BIT's 9th Annual Congress of International Drug Discovery Science and Technology (IDDST-2011)   2011   

Works

 
Synthseses and enzyme inihibition test of flavin anlogs as antitumor agents
2009
Flavin analogs possessing enzyme inhibition as anititumor agents
2009
Research on Synthesis of Nucleic acid Analogs
Research on Synthesis of Novel Compounds for Anti-coccidiosis and Anti-malaria
Research on the Bacterial Toxin of Pathogen Factor Causing the Withering of Crops.

Research Grants & Projects

 
Study on Synthesis of Antitumor-active Flavin, Deazaflavin and Azapteridine Analogues and Their Structure-Activity Relationship
Grants and Funding
Project Year: 1990   
The Invention of Novel Fused Pyrimidines as Organic Catalysts and NAD(P)+ and /or Flavin Models and the Research of Autorecycling Redox Using them.
Grant-in-Aid for Scientific Research
Project Year: 1990   
Synthesis and Evaluation of Fused Pyrimidines, Purines and their Nucleosides.
Cooperative Research
Project Year: 1990   
Study on Synthesis of Polycyclic Codensed Purine and Pyrazolopyrimidine Derivatives as Xanthine Oxidase Inhibitors and Their Structure-Activity Relationship
Grant-in-Aid for Scientific Research
Project Year: 1996   
Synthesis and Molecular Design of Steroids Hybridized by Pteridine and Deazapteridine Having Various Physiological Activities and Anti-tumor activity
Grant-in-Aid for Scientific Research
Project Year: 2000   

Patents

 
Preparation of oxazolinylphosphine oxide derivatives as condensing agents.
Jpn. Kokai Tokkyo Koho JP 01,197,446
Preparation of purine derivatives as learning and memory improvers.
PCT Int. Appl. WO 97 06,169
Herbicides containing 7-azapteridines.
Jpn. Kokai Tokkyo Koho JP 10 175,807
Preparation of 4-substituted-1H-6-oxopyrazolo[3,4-d]pyrimidines as xanthine oxidase inhibitors.
Jpn. Kokai Tokkyo Koho JP 11 140,086
Preparation of 3-substituted-7H-pyrazolo[4,3-e]-1,2,4-triazolo[3,4-c]pyrimidine compounds as xanthine oxidase inhibitors.
Jpn. Kokai Tokkyo Koho JP 11 246,560