2001年
Synthesis and antimalarial activity of febrifugine derivatives
Chemical and Pharmaceutical Bulletin
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- 巻
- 49
- 号
- 6
- 開始ページ
- 721
- 終了ページ
- 725
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1248/cpb.49.721
The regioisomers (2a,b) of the piperidine ring of febrifugine (1a) and isofebrifugine (1b) were synthesized from 4-allyl-3-piperidone (5). Reduction of 5 afforded a mixture of the trans and cis alcohols (6a,b) without diastereoselectivity
this result differentiated it from the reduction of 2-allyl-3-piperidone (14). The antimalarial di-activity of 2a,b and related compounds was tested.
this result differentiated it from the reduction of 2-allyl-3-piperidone (14). The antimalarial di-activity of 2a,b and related compounds was tested.
- ID情報
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- DOI : 10.1248/cpb.49.721
- ISSN : 0009-2363
- PubMed ID : 11411524
- SCOPUS ID : 0034962101