2014年7月
Polycyclic N-Heterocyclic Compounds. Part 75: Synthesis of 2,4-Disubstituted 5,6-dihydro[1]benzoxepino[5,4-d]pyrimidines and 12-Substituted 1,2,4,5-Tetrahydro[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines as Potential Antiplatelet Aggregators
JOURNAL OF HETEROCYCLIC CHEMISTRY
- ,
- ,
- ,
- 巻
- 51
- 号
- 4
- 開始ページ
- 972
- 終了ページ
- 981
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1002/jhet.1559
- 出版者・発行元
- WILEY-BLACKWELL
Libraries of tricyclic 2-substituted 4-alkylamino-5,6-dihydro[1]benzoxepino[5,4-d]pyrimidines and tetracyclic 12-substituted 1,2,4,5-tetrahydro[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines were synthesized as part of our research to develop new effective antiplatelet drugs. Several alkyl and aryl groups were used as substituents at the 2-position. Evaluation of the effects of the newly synthesized compounds on collagen-induced platelet aggregation revealed several promising antiplatelet candidates with potencies superior to aspirin.
- リンク情報
- ID情報
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- DOI : 10.1002/jhet.1559
- ISSN : 0022-152X
- eISSN : 1943-5193
- Web of Science ID : WOS:000340277200013