2010年5月
Hydrolyzable Tannins of Tamaricaceous Plants. III. Hellinoyl- and Macrocyclic-Type Ellagitannins from Tamarix nilotica
JOURNAL OF NATURAL PRODUCTS
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- 巻
- 73
- 号
- 5
- 開始ページ
- 870
- 終了ページ
- 879
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/np900829g
- 出版者・発行元
- AMER CHEMICAL SOC
Three new hellinoyl-type ellagitannins, nilotinins M4 (7), D7 (8), and D8 (9), and a new macrocyclic-type, nilotinin D9 (10), together with eight known tannins, hirtellins B (2), C (11), and F (12), isohirtellin C (13), tamarixinin A (3), tellimagrandins I and II, and 1,2,6-tri-O-galloy-beta-D-glucose (14), were isolated from an aqueous acetone extract of Tamarix nilotica dried leaves. Nilotinin M4 (7) is a monomeric tannin possessing a hellinoyl moiety. The structure of 8 demonstrated replacement of one of the HHDP groups at the glucose core O-4/O-6 in ordinary dimeric tannins with a galloyl moiety at O-6. This is a new structural feature among the tamaricaceous ellagitannins. On the basis of the results, reported spectroscopic assignments for 2, 3, and the macrocyclic tannins 11-13 were revised. Unusual shifts in the NMR spectra of these macrocyclic tannins are also discussed in relation to their conformations. Several tannins isolated from T nilotica were assessed for possible cytotoxic activity against four human tumor cell lines, and nilotinin D8 (9) and hirtellin A (1) showed high cytotoxic effects.
- リンク情報
- ID情報
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- DOI : 10.1021/np900829g
- ISSN : 0163-3864
- Web of Science ID : WOS:000278080900015