論文

2010年5月

Hydrolyzable Tannins of Tamaricaceous Plants. III. Hellinoyl- and Macrocyclic-Type Ellagitannins from Tamarix nilotica

JOURNAL OF NATURAL PRODUCTS
  • Mohamed A. A. Orabi
  • ,
  • Shoko Taniguchi
  • ,
  • Morio Yoshimura
  • ,
  • Takashi Yoshida
  • ,
  • Kaori Kishino
  • ,
  • Hiroshi Sakagami
  • ,
  • Tsutomu Hatano

73
5
開始ページ
870
終了ページ
879
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/np900829g
出版者・発行元
AMER CHEMICAL SOC

Three new hellinoyl-type ellagitannins, nilotinins M4 (7), D7 (8), and D8 (9), and a new macrocyclic-type, nilotinin D9 (10), together with eight known tannins, hirtellins B (2), C (11), and F (12), isohirtellin C (13), tamarixinin A (3), tellimagrandins I and II, and 1,2,6-tri-O-galloy-beta-D-glucose (14), were isolated from an aqueous acetone extract of Tamarix nilotica dried leaves. Nilotinin M4 (7) is a monomeric tannin possessing a hellinoyl moiety. The structure of 8 demonstrated replacement of one of the HHDP groups at the glucose core O-4/O-6 in ordinary dimeric tannins with a galloyl moiety at O-6. This is a new structural feature among the tamaricaceous ellagitannins. On the basis of the results, reported spectroscopic assignments for 2, 3, and the macrocyclic tannins 11-13 were revised. Unusual shifts in the NMR spectra of these macrocyclic tannins are also discussed in relation to their conformations. Several tannins isolated from T nilotica were assessed for possible cytotoxic activity against four human tumor cell lines, and nilotinin D8 (9) and hirtellin A (1) showed high cytotoxic effects.

リンク情報
DOI
https://doi.org/10.1021/np900829g
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000278080900015&DestApp=WOS_CPL
ID情報
  • DOI : 10.1021/np900829g
  • ISSN : 0163-3864
  • Web of Science ID : WOS:000278080900015

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