The erychrocyte sedimentation rate is a useful qualitative index in various clinical cases. As the mechanism of erythrocyte sedimentation is multifaceted, many experimen-tal and theoretical investigations have been done. Despite the large number of models developed in previous studies, no model has proven to be a comprehensive solution. In this paper a new aggregation and sedimentation model is proposed. The model utilizes underlying Stokes' equation that describes the sedimentation velocity of single rigid particle. It involves the use of some formulas obtained experimentally in previous investigations and describes a mechanism of erythrocyte sedimentation that consists of aggregation of erythrocytes, sedimentation of aggregates and packing of erythrocytes. The prediction of the erythrocyte sedimentation curve and sedimentation rate is made possible by inserting hematocrit, hemoglobin and some plasma protein concentration values into the equations of the model. A good agreement between the observed and predicted values was obtained.