Shinya Koyama

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Affiliation: Professor, Department of Pharmacology, Shujitsu University

Degree: Doctor of Medical Science

J-GLOBAL ID: 200901006979968813
researchmap Member ID: 1000036185

Research Interests

Research Areas

Research History

Education

- 1986

Hiroshima University
- 1986

Graduate School, Division of Medical Sciences, Hiroshima University
- 1981

School of Medicine, Faculty of Medicine, Hiroshima University
- 1981

Faculty of Medicine, Hiroshima University

Misc.

Ubquitin-interacting motifs of epsin are involved in the regulation of insulin-dependent endocytosis

S Sugiyama, S Kishida, K Chayama, S Koyama, A Kikuchi

JOURNAL OF BIOCHEMISTRY, 137(3) 355-364, Mar, 2005
Ubquitin-interacting motifs of epsin are involved in the regulation of insulin-dependent endocytosis

S Sugiyama, S Kishida, K Chayama, S Koyama, A Kikuchi

JOURNAL OF BIOCHEMISTRY, 137(3) 355-364, Mar, 2005
Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration

T Oshiro, S Koyama, S Sugiyama, A Kondo, Y Onodera, T Asahara, H Sabe, A Kikuchi

JOURNAL OF BIOLOGICAL CHEMISTRY, 277(41) 38618-38626, Oct, 2002
Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration

T Oshiro, S Koyama, S Sugiyama, A Kondo, Y Onodera, T Asahara, H Sabe, A Kikuchi

JOURNAL OF BIOLOGICAL CHEMISTRY, 277(41) 38618-38626, Oct, 2002
Regulators and Effectors of Small GTPases. Part F Ras Family I, Section I. Protein Expression and Protein-Protein Interactions. 9. Ras Interaction with RalGDS Effector Targets

Methods Enzymol., 332 127-138, 2001
Regulation of complex formation of POB1/Epsin/adaptor protein complex 2 by mitotic phosphorylation

Kenji Kariya, Shinya Koyama, Shintaro Nakashima, Takafumi Oshiro, Kenji Morinaka, Akira Kikuchi

Journal of Biological Chemistry, 275(24) 18399-18406, Jun 16, 2000
Regulation of Complex Formation of POB1/Epsin/Adaptor Complex 2 by Mitotic Phosphorylation.

J. Biol. Chem., 275, 18399-18406, 2000
Regulation of Complex Formation of POB1/Epsin/Adaptor Complex 2 by Mitotic Phosphorylation.

J. Biol. Chem., 275, 18399-18406, 2000
Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis

K Morinaka, S Koyama, S Nakashima, T Hinoi, K Okawa, A Iwamatsu, A Kikuchi

ONCOGENE, 18(43) 5915-5922, Oct, 1999
The Drosophila Ral GTPase regulates developmental cell shape changes through the jun NH2-terminal kinase pathway

K Sawamoto, P Winge, S Koyama, Y Hirota, C Yamada, S Miyao, S Yoshikawa, MH Jin, A Kikuchi, H Okano

JOURNAL OF CELL BIOLOGY, 146(2) 361-372, Jul, 1999
Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors

S Nakashima, K Morinaka, S Koyama, M Ikeda, M Kishida, K Okawa, A Iwamatsu, S Kishida, A Kikuchi

EMBO JOURNAL, 18(13) 3629-3642, Jul, 1999
Axin prevents Wnt-3a-induced accumulation of β-catenin

Michiko Kishida, Shinya Koyama, Shosei Kishida, Kenji Matsubara, Shintaro Nakashima, Keiichi Higano, Ritsuko Takada, Shinji Takada, Akira Kikuchi

Oncogene, 18(4) 979-985, Jan 28, 1999
Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors.

EMBO J., 18, 3629-3642, 1999
Epsin binds to the EH domain of POB1 andregulates receptor-mediated endocytosis.

Oncogene, 18, 5915-5922, 1999
Axin prevents Wnt-3a-induced accumulation of beta-catenin

M Kishida, S Koyama, S Kishida, K Matsubara, S Nakashima, K Higano, R Takada, S Takada, A Kikuchi

ONCOGENE, 18(4) 979-985, Jan, 1999
Axin, a negative regulator of the Wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of β-catenin

Shosei Kishida, Hideki Yamamoto, Satoshi Ikeda, Michiko Kishida, Ikuo Sakamoto, Shinya Koyama, Akira Kikuchi

Journal of Biological Chemistry, 273(18) 10823-10826, May 1, 1998
Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3 beta and beta-catenin and inhibits axis formation of Xenopus embryos

H Yamamoto, S Kishida, T Uochi, S Ikeda, S Koyama, M Asashima, A Kikuchi

MOLECULAR AND CELLULAR BIOLOGY, 18(5) 2867-2875, May, 1998
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK-3β-dependent phosphorylation of β-catenin

Satoshi Ikeda, Shosei Kishida, Hideki Yamamoto, Hiroshi Murai, Shinya Koyama, Akira Kikuchi

EMBO Journal, 17(5) 1371-1384, Mar 2, 1998
Interactions of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1 and RalGDS

M Shirouzu, K Morinaka, S Koyama, CD Hu, N Hori-Tamura, T Okada, K Kariya, T Kataoka, A Kikuchi, S Yokoyama

JOURNAL OF BIOLOGICAL CHEMISTRY, 273(13) 7737-7742, Mar, 1998
Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3β and β-catenin and inhibits axis formation of Xenopusembryos.

Mol. Cell. Biol., 18, 2867-2875, 1998

Books and Other Publications

Ras interaction with RalGDS effector targets.

Methods Enzymol., 2001
神経疾患理解のための病態生理

別冊・医学の歩み神経疾患―state of arts Ver. 1 医歯薬出版, 1999

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Education

Misc.

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