2001年2月
Emergence of anti-inflammatory monocytes in long-term surviving hosts of IL-10-transduced liver allografts
CYTOKINE
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- 巻
- 13
- 号
- 3
- 開始ページ
- 183
- 終了ページ
- 187
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1006/cyto.2000.0810
- 出版者・発行元
- W B SAUNDERS CO
We previously reported that transduction of IL-10 to rat liver allografts facilitates survival prolongation after orthotopic liver transplantation (OLT). In the current study, we examined Lewis hosts of IL-10-transduced allografts that had survived longer than 50 days in order to characterize peripheral blood mononuclear cells (PBMC). Phenotype analysis of the PBMC demonstrated an 18-fold increase in monocytes (CD11b/c(+)) with a massive increase in the monocyte/lymphocyte ratio. The monocytes expressed downregulated MHC class II (RT1B) but upregulated Fc gamma receptors in comparison with monocytes from the control hosts. The capacity of enriched monocytes to secrete TNF-alpha in response to LPS stimulation was downregulated in the survivors, while production of IL-10 was comparable. The monocytes from long-term survivors significantly inhibited the donor antigen stimulated secretion of IFN-gamma and IL-2. Monocytosis characterized by a shift to anti-inflammatory monocytes is associated with survival prolongation in the hosts of IL-10 transduced liver allografts. (C) 2001 Academic Press.
- リンク情報
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- DOI
- https://doi.org/10.1006/cyto.2000.0810
- CiNii Articles
- http://ci.nii.ac.jp/naid/80012240963
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/11161463
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000166915600009&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1006/cyto.2000.0810
- ISSN : 1043-4666
- CiNii Articles ID : 80012240963
- PubMed ID : 11161463
- Web of Science ID : WOS:000166915600009