2007年3月
Development of recombinant chicken IgY from single chain fragment of variable region for diagnosis of BSE
BIOLOGICALS
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- 巻
- 35
- 号
- 1
- 開始ページ
- 31
- 終了ページ
- 34
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1016/j.biologicals.2006.01.003
- 出版者・発行元
- ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
We generated two recombinant chicken IgYs, designated Ab3-15 and Ab4-19, against mammalian prion protein (PrP) from the single chain fragment of variable region (scFv) antibodies. These two antibodies recognized PrPSc from bovine spongiform encephalopathy (BSE) in cattle and were more sensitive than the corresponding scFv antibodies. These antibodies also recognized PrPSc from other sccapie-infected mammals. These results indicate that Ab3-15 and Ab4-19 are useful for diagnosis of BSE as well as other prion diseases. (c) 2006 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.biologicals.2006.01.003
- ISSN : 1045-1056
- Web of Science ID : WOS:000244956600006