MISC

2003年1月

Antiangiogenic properties of a sulfated galactan isolated from a marine green alga, Codium cylindricum

JOURNAL OF APPLIED PHYCOLOGY
  • K Matsubara
  • ,
  • M Mori
  • ,
  • H Matsumoto
  • ,
  • K Hori
  • ,
  • K Miyazawa

15
1
開始ページ
87
終了ページ
90
記述言語
英語
掲載種別
DOI
10.1023/A:1022958222915
出版者・発行元
KLUWER ACADEMIC PUBL

An anticoagulant sulfated galactan isolated from the marine green alga, Codium cylindricum, was shown to have antiangiogeinic activity. This galactan suppressed microvessel formation in an ex vivo serum-free matrix culture model using rat aortic ring. It also inhibited human umbilical vein endothelial cells (HUVEC) tube formation on reconstituted basement membrane gel. These results show the value of algal sulfated galactans in the design of antiangiogenic agents.

Web of Science ® 被引用回数 : 19

リンク情報
DOI
https://doi.org/10.1023/A:1022958222915
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000181768200011&DestApp=WOS_CPL