1999年6月
Role of type III iodothyronine 5-deiodinase gene expression in temporal regulation of Xenopus metamorphosis
DEVELOPMENT GROWTH & DIFFERENTIATION
- ,
- ,
- 巻
- 41
- 号
- 3
- 開始ページ
- 365
- 終了ページ
- 373
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1046/j.1440-169X.1999.413431.x
- 出版者・発行元
- BLACKWELL SCIENCE ASIA
To elucidate the role of type III iodothyronine 5-deiodinase (5-D) in the temporal regulation of amphibian metamorphosis, the regulation of gene expression of 5-D and thyroid hormone receptor beta (TR beta) in organs of Xenopus laevis was investigated. High levels of TR beta mRNA in the respective organs were observed at the times of their major morphological changes. Expression of the 5-D gene was highly regulated among the organs during metamorphosis, including up-regulation in the tail and down-regulation in the liver. The tail and liver expressed 5-D gene before their metamorphic changes. These precocious expressions correlated with the lower responsiveness to exogenously added triiodo-L-thyronine (T-3) for inducing a high level of TR beta mRNA expression. However, the same organs responded to lower doses of T-3 to regulate 5-D gene expression as seen in spontaneous metamorphosis. The induction of 5-D gene expression was considerably delayed in the intestine, even at an excess dose of T-3. Thus, the two genes in a given organ appeared to respond to T-3 either with different dose dependencies or with different timetables. The results obtained are also discussed in respect to recent findings in Rana catesbeiana.
- リンク情報
- ID情報
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- DOI : 10.1046/j.1440-169X.1999.413431.x
- ISSN : 0012-1592
- CiNii Articles ID : 10009426587
- Web of Science ID : WOS:000081646400013