Reproductive success of individual animals is essential for the survival of any species. Molluscs have adapted to a wide variety of environments ( freshwater, brackish water, seawater, and terrestrial habits) and have evolved unique tactics for reproduction. Both of these features attract the academic interests of scientists. Because neuropeptides and peptide hormones play critical roles in neural and neurohormonal regulation of physiological functions and behaviors in this animal group, the regulatory actions of these messengers in reproduction have been extensively investigated. In this review, we will briefly summarize how peptidergic messengers are involved in various aspects of reproduction, using some peptides such as egg-laying hormone, caudo-dorsal cell hormone, APGWamide, and gonadotropin-releasing hormone as typical examples.