UTSUMI Toshihiko

J-GLOBAL         Last updated: Oct 3, 2019 at 16:23
 
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Name
UTSUMI Toshihiko
E-mail
utsumiyamaguchi-u.ac.jp
Affiliation
Yamaguchi University
Section
Graduate School of Medicine Applied Molecular Bioscience(Agriculture) Graduate School of Medicine(Agriculture) YAMAGUCHI UNIVERSITY
Job title
Professor
Degree
(BLANK)(Kyushu University)
Other affiliation
Yamaguchi UniversityYamaguchi UniversityYamaguchi UniversityYamaguchi University
Research funding number
20168727

Research Areas

 
 

Academic & Professional Experience

 
Feb 2010
 - 
May 2010
Graduate School of Medicine(Agriculture), YAMAGUCHI UNIVERSITY
 
May 2010
 - 
Apr 2016
Professor, Graduate School of Medicine(Agriculture), YAMAGUCHI UNIVERSITY
 

Education

 
 
 - 
1980
Faculty of Agriculture, Kyushu University
 
 
 - 
Mar 1983
Graduate School, Division of Agriculture, Kyushu University
 

Published Papers

 
Utsumi T, Matsuzaki K, Kiwado A, Tanikawa A, Kikkawa Y, Hosokawa T, Otsuka A, Iuchi Y, Kobuchi H, Moriya K
PloS one   13(11) e0206355   Nov 2018   [Refereed]
Shunya Saito, Shin Hamamoto, Koko Moriya, Aiko Matsuura, Yoko Sato, Jun Muto, Hiroto Noguchi, Seiji Yamauchi, Yuzuru Tozawa, Minoru Ueda, Kenji Hashimoto, Philipp Köster, Qiuyan Dong, Katrin Held, Jörg Kudla, Jörg Kudla, Toshihiko Utsumi, Nobuyuki Uozumi
New Phytologist   218 1504-1521   Jun 2018   [Refereed]
© 2018 The Authors. New Phytologist © 2018 New Phytologist Trust N-myristoylation and S-acylation promote protein membrane association, allowing regulation of membrane proteins. However, how widespread this targeting mechanism is in plant signalin...
Koko Moriya, Kei Nagatoshi, Yoshimi Noriyasu, Tsuyoshi Okamura, Emi Takamitsu, Takashi Suzuki, Toshihiko Utsumi
PLOS ONE   8(11) e78235   Nov 2013   [Refereed]
N-myristoylation of eukaryotic cellular proteins has been recognized as a modification that occurs mainly on cytoplasmic proteins. In this study, we examined the membrane localization, membrane integration, and intracellular localization of four r...
Hideki Hanada, Hirotsugu Kobuchi, Masanao Yamamoto, Keiko Kashiwagi, Kenjiro Katsu, Toshihiko Utsumi, Akihiko Kashiwagi, Akihiko Kashiwagi, Junzo Sasaki, Masayasu Inoue, Kozo Utsumi
Hereditas   150 1-9   Feb 2013   [Refereed]
Mitochondrial membrane permeability transition (MPT) plays a crucial role in apoptotic tail shortening during anuran metamor phosis. L-carnitine is known to shuttle free fatty acids (FFAs) from the cytosol into mitochondria matrix for β-oxidation ...
Toshihiko Utsumi
Seikagaku   82 799-813   Dec 2010   [Refereed]
Seiji Yamauchi, Naoki Fusada, Naoki Fusada, Hidenori Hayashi, Toshihiko Utsumi, Nobuyuki Uozumi, Yaeta Endo, Yaeta Endo, Yuzuru Tozawa, Yuzuru Tozawa
FEBS Journal   277 3596-3607   Jan 2010   [Refereed]
Protein N-myristoylation plays key roles in various cellular functions in eukaryotic organisms. To clarify the relationship between the efficiency of protein N-myristoylation and the amino acid sequence of the substrate in plants, we have applied ...
Amo, T., Kawanishi, N., Uchida, M., Fujita, H., Oyanagi, E., Utsumi, T., Inoue, K., Shuin, T., Utsumi, K., Sasaki, J
Cell Biochem. Funct.   27 503-515   2009   [Refereed]
Moriya, K., Hirakura, S., Kobayashi, J., Ozoe, Y., Saito, S., Utsumi, T.
Arch. Insect Biochem. Physiol.   69 22-31   2008   [Refereed]
Fujita, H., Shiosaka, M., Ogino, T., Okimura, Y., Utsumi,T., Sato, E., Akagi,R., Inoue, M., Utsumi, K., Sasaki, J
Brain Res.   1206 1-12   2008   [Refereed]
Suzuki, T., Ito, M., Ezure, T., Shikata, M., Ando, E., Utsumi, T., Tsunasawa, S., Nishimura, O.
Biosci. Biotech. Biochem.   71 261-264   2007   [Refereed]
Suzuki, T., Ito, M., Ezure, T., Shikata, M., Ando, E., Utsumi, T., Tsunasawa, S., Nishimura, O.
Proteomics   7 1942-1950   2007   [Refereed]
Sakurai, N., Moriya, K., Suzuki, T., Sofuku, K., Mochiki, H., Nishimura, O., Utsumi, T.
Anal. Biochem.   362 236-244   2007   [Refereed]
Suzuki, T., Ito, M., Ezure, T., Shikata, M., Ando, E., Utsumi, T., Tsunasawa, S., Nishimura, O.
Proteomics   6 4486-4495   2006   [Refereed]
Fujita, H., Okimura, Y., Utsumi, T., Kitamura, S., Kuroki, H., Otsuki, T., Sasaki, J., Kashiwagi, A., Utsumi, K
J. Clin. Biochem. Nutr.   38 167-175   2006   [Refereed]
Toshihiko Utsumi
Seikagaku. The Journal of Japanese Biochemical Society   75 373-378   May 2003   [Refereed]
J. Biol. Chem.   278, 40373-40384    2003   [Refereed]
Insect Mol. Biol.   12, 217-223    2003   [Refereed]
Biosci. Biotech. Biochem.   66, 1865-1872    2002   [Refereed]
Acta Anaesthesiol Scand.   46, 1068-74    2002   [Refereed]
Mitochondrial swelling and cytochrome c release : Sensitivity to cyclosporin A and calcium.
Physiol. Chem. & Physics.   34, 91-102    2002   [Refereed]
Mevastatin, an inhibitor of HMG-CoA reductase, induces apoptosis, differentiation and rap1 expression in HL-60 cells
Physiol. Chem. & Physics.   34, 1-15    2002   [Refereed]
Kayo Arita, Kayo Arita, Tomoko Kanno, Yoshiki Takehara, Takuzo Fujiwara, Jitsuo Akiyama, Alan A. Horton, Toshihiko Utsumi
Physiological Chemistry and Physics and Medical NMR   33 121-132   Dec 2001   [Refereed]
Polymorphonuclear leukocytes from healthy volunteers (HPMN) generated superoxide (O2.-) following treatment with various stimuli, such as phorbol myristate acetate (PMA), opsonized zymozan (OZ) and arachidonic acid (AA). Other types of n-3 polyuns...
Comp. Biochem. Phys.   130, 411-418    2001   [Refereed]
Biochem. Pharmacol.   62, 1037-1046    2001   [Refereed]
FEBS Letters   500(1-2) 1-6   2001   [Refereed]
Biochemical Pharmacology   60 905-915   2000   [Refereed]
Rumi Ishisaka, Noriyuki Sato, Kenji Tanaka, Tomonori Takeshige, Hiroyuki Iwata, Jim Klostergaard, Toshihiko Utsumi
Journal of Biochemistry   126 413-420   Jan 1999   [Refereed]
To determine the minimum requirement in the 76-residue leader sequence of pro-tumor necrosis factor (TNF) for membrane translocation across the endoplasmic reticulum (ER) and for the maturation of pro-TNF, we constructed pro-TNF mutants in which a...
50(2) 117-126   1999   [Refereed]
Cell Structure and Function   24 465-470   1999   [Refereed]
Rumi Ishisaka, Rumi Ishisaka, Tomoko Kanno, Tomoko Kanno, Hiroshi Kanematsu, Toshihiko Utsumi, Jitsuo Akiyama, Alan A. Horton, Tamotsu Yoshioka
Physiological Chemistry and Physics and Medical NMR   30 1-13   Dec 1998   [Refereed]
Lactoferrin (LF) is an iron-binding glycoprotein present in various secretions including milk and the specific granules of neutrophils. The main biological properties of this protein are thought to concern the regulation of iron absorption, antimi...
FEBS Letters   435 233-236   1998   [Refereed]
Archives of Biochemistry and Biophysics   349 216-224   1998   [Refereed]
Role of cellular processing of TNF-α in the expression of its biological function.
69(10) 1004-1010   1997   [Refereed]
Shigemichi Iha, Kunzo Orita, Tomoko Kanno, Tomoko Kanno, Toshihiko Utsumi, Eisuke F. Sato, Masayasu Inoue, Kozo Utsumi
Free Radical Research   25 489-498   Jan 1996   [Refereed]
Tomoko Kanno, Tomoko Kanno, Toshihiko Utsumi, Yoshiki Takehara, Akio Ide, Jitsuo Akiyama, Tamotsu Yoshioka, Alan A. Horton, Kozo Utsumi, Kozo Utsumi
Free Radical Research   24 281-289   Jan 1996   [Refereed]
K. Akimaru, E. Auzenne, Y. Akimaru, M. E. Leroux, A. C. Hayman, T. Utsumi, G. I. Soma, J. Klostergaard
Cytokines and Molecular Therapy   1 197-210   Sep 1995   [Refereed]
Yoshiya Watanabe, Keisuke E-ige, Hirotsugu Kobuchi, Yoji Kato, Tatsuomi Matsuoka, Toshihiko Utsumi, Tamotsu Yoshioka, Alan A. Horton, Kozo Utsumi
Biochemical Pharmacology   49 529-536   Feb 1995   [Refereed]
Blepharismin is an endogenous photosensitizing pigment found in the protozoan Blepharisma. This pigment inhibited the generation of Superoxide anion (O2-) in neutrophils not only via a diacylglycerol-induced protein kinase C (PKC)-dependent reacti...
Tomoko Kanno, Toshihiko Utsumi, Hirotsugu Kobuchi, Yoshiki Takehara, Jitsuo Akiyama, Tamotsu Yoshioka, Alan A. Horton, Kozo Utsuml, Kozo Utsuml
Free Radical Research   22 431-440   Jan 1995   [Refereed]
Alpha-tocopherol but not 2-carboxy-2,5,7,8-tetramethyl-6-chromanol (trolox or CTMC) and 2,2,5,7,8 pentamethyl-6-hydroxy chromane (PMC), derivatives of αtocopherol, inhibited the superoxide (O2-) generation of rat peritoneal neutrophils (RPMN) indu...
Takahiko Utsumi, Minoru Okuma, Toshihiko Utsumi, Tomoko Kanno, Tatsuji Yasuda, Hirotsugu Kobuchi, Alan A. Horton, Kozo Utsumi
Archives of Biochemistry and Biophysics   316 493-497   Jan 1995   [Refereed]
Hypericin, a photosensitizing plant pigment, has antiretroviral activity. When exposed to light, the inhibition of Friend leukemia virus (FLV)-induced splenomegaly by hypericin was increased. The ID50was decreased to less than 2.5 μg/mouse by expo...
Human Pro-Tumor Necrosis Factor : Molecular Determinants of Membrane Translocation,Sorting,and Maturation
Molecular and Cellular Biology   15(11) 6398-6405   1995   [Refereed]
Tomoko Kanno, Toshihiko Utsumi, Akio Ide, Yoshiki Takehara, Toshiji Saibara, Jitsuo Akiyama, Tamotsu Yoshioka, Kozo Utsumi
Free Radical Research   21 223-234   Jan 1994   [Refereed]
Mouse liver mitochondria were uncoupled in a time dependent by intraperitoneal injection of a radical initiator, 2,2'azobis-(2-amidinopropane) dihydrochloride (AAPH) (100mg/kg). State 3 respiration, ADP/O ratio and respiratory control ratio (RCR) ...
Nippon N(]E87C7[)geikgaku Kaishi   68(11) 1551   1994   [Refereed]
Archives of Biochemistry and Biophysics   313(2) 337   1994   [Refereed]
Effects of truncation of human pro-tumor necrosis factor transmembrane domain on cellular targeting
The Journal of Biological Chemistry   268(13) 9511-9516   1993   [Refereed]
Molecular mechanism for intracellular processing of human pro-TNF
Lymphokine and Cytokine Research   12(5) 375   1993   [Refereed]
Kunihiro Akimaru, Toshihiko Utsumi, Eisuke F. Sato, Jim Klostergaard, Masayasu Inoue, Kozo Utsumi
Archives of Biochemistry and Biophysics   298 703-709   Nov 1992   [Refereed]
The ability of human tumor necrosis factor-α (TNF-α) and human granulocyte colony stimulating factor (G-CSF) to induce phosphorylation of protein tyrosyl residues in human peripheral neutrophils (PMN) was investigated by Western blot analysis with...
Masanobu Tanimura, Hirotsugu Kobuchi, Toshihiko Utsumi, Tamotsu Yoshioka, Shinichi Kataoka, Yukitoshi Fujita, Kozo Utsumi
Biochemical Pharmacology   44 1045-1052   Sep 1992   [Refereed]
Upon stimulation by various ligands, freshly isolated human peripheral neutrophils (PMN) respond in a variety of ways, such as Superoxide (O-2) generation, phagocytosis, enzyme release, migration etc. Chemotactic peptide formylmethionyl-leucyl-phe...
T. Utsumi, J. Klostergaard, K. Akimaru, E. F. Sato, T. Yoshioka, K. Utsumi
Physiological chemistry and physics and medical NMR   24 77-88   Jan 1992   [Refereed]
Preincubation of human peripheral blood polymorphonuclear leukocytes (HPPMN) with recombinant human tumor necrosis factor-alpha (rHuTNF-alpha) enhanced the formylmethionyl-leucylphenylalanine (FMLP)-induced superoxide (O2-.) generation in a concen...
Keisuke Edashige, Toshihiko Utsumi, Eisuke F. Sato, Akio Ide, Magosaburo Kasai, Kozo Utsumi
Archives of Biochemistry and Biophysics   296 296-301   Jan 1992   [Refereed]
To clarify the requirement of the association of substrate proteins with phospholipid membranes for phosphorylation by protein kinase C (PKC), we studied the relationship between membrane association of PKC-substrate proteins and their phosphoryla...
Masayasu Inoue, Nobukazu Watanabe, Toshihiko Utsumi, Junzo Sasaki
Free Radical Research   12 391-399   Jan 1991   [Refereed]
Although oxygen toxicity of tissues can be decreased by a variety of antioxidants and some enzymes, such as SOD and catalase, their protective effect on tissue injury in various diseases are fairly small predominantly because of their unfavorable ...
Toshihiko Utsumi, Jim Klostergaard, Mien Chie Hung, Jim Klostergaard
Cancer Research   51 3362-3366   Jan 1991   [Refereed]
The liposomal delivery of rccombinanl human tumor necrosis factor (rHuTNF) has been shown to be effective in reducing its toxic effects and in its targeting of organs rich in cells of the rcticuloendothelial system. However, native recombinant hum...
Keisuke Edashige, Toshihiko Utsumi, Kozo Utsumi
Biochemical Pharmacology   41 71-78   Jan 1991   [Refereed]
In two-stage mouse skin carcinogenesis initiated by 7,12-dimethylbenz[α]anthracene (DMBA), cepharanthine inhibited the tumor promoting activity of 12-O-tetradecanoyl phorbol-13-acetate (TPA). Since Ca2+-phospholipid-dependent protein kinase (PKC) ...
Agricultural and Biological Chemistry   54(1)    1990   [Refereed]
Daizo Koga, Hidehiro Fujimoto, Takushi Funakoshi, Toshihiko Utsumi, Akio Ide
Insect Biochemistry   19 123-128   Jan 1989   [Refereed]
The appearance of chitinolytic enzymes, chitinase and β-N-acetylglucosaminidase, involved in ecdysis of the silkworm, Bombyx mori, was investigated using integuments prepared from fifth instar larvae during and after spinning behavior just before ...
Gunki Funatsu, Keiichi Watanabe, Toshihiko Utsumi
Agricultural and Biological Chemistry   53 1173-1174   Jan 1989   [Refereed]
Daizo Koga, Tsuyoshi Tsukamoto, Nobuyuki Sueshige, Toshihiko Utsumi, Akio Ide
Agricultural and Biological Chemistry   53 3121-3126   Jan 1989   [Refereed]
Kinetic analysis was done on chitinase E3 (EC 3.2.1.14) from yam, Dioscorea opposita Thunb, using both series of N-acetylchitooligosaccharides (GlcNAcnn = 2 to 6) and p-nitrophenyl N- acetylchitooligosaccharides (pNp-GlcNAcnn = 1 to 5) as substrat...
FEBS Letters   242(2)    1989   [Refereed]
Yukio Ando, Masayasu Inoue, Toshihiko Utsumi, Yoshimasa Morino, Shukuro Araki
FEBS Letters   240 216-220   Nov 1988   [Refereed]
Involvement of oxygen radicals in the pathogenesis of various inflammatory diseases has been the focus of recent attention. Since lipid peroxidation of cell membranes is postulated to be one of the major reasons for radical-induced tissue injury, ...
Daizo Koga, Nobuyuki Sueshige, Kazuhiko Orikono, Toshihiko Utsumi, Akio Ide, Shuhei Tanaka, Yoshio Yamada
Agricultural and Biological Chemistry   52 2091-2093   Jan 1988   [Refereed]
Shigeo Terada, Koichi Nobori, Kozo Utsumi, Toshihiko Utsumi
Cell Structure and Function   13 359-371   Jan 1988   [Refereed]
We have studied protein acylation in neutrophils of guinea pigs using [3H]myristate. A large number of neutrophil proteins were acylated with exogenously added myristic acid. The myristoylation was detected on 110, 77, 56, 54, 52, 42, and 37 kDa p...
E. Sato, K. Edashige, T. Utsumi, B. Inoue, M. Miyahara, K. Utsumi
Physiological chemistry and physics and medical NMR   18 79-87   Dec 1986   [Refereed]
Various stimuli act on polymorphonuclear leukocytes (PMN), activating membrane-bound phospholipase A2 and C, and diglyceride lipase and then liberating unsaturated fatty acids (USFAs). These liberated USFAs are immediately metabolized through vari...
Eiji Okimasu, Masazumi Yamamoto, Kozo Utsumi, Yoshitaka Fujii, Toshihiko Utsumi
Cell Structure and Function   11 273-283   Jan 1986   [Refereed]
Since the plasticity of the plasma membrane is correlated with changes in its dynamic behavior and biological functions, the content of cholesterol in this membrane is thought to have an important role in the regulation of cell metabolism. The res...
Toshihiko Utsumi, Gunki Funatsu
Agricultural and Biological Chemistry   50 1047-1049   Jan 1986   [Refereed]
Kozo Utsumi, Koichi Nobori, Shigeo Terada, Masanobu Miyahara, Toshihiko Utsumi
Cell Structure and Function   10 339-348   Jan 1985   [Refereed]
The amount of free calcium in the cytoplasm is important in stimulation coupled with a number of cellular functions. The putative ionophoretic action of membrane lipid metabolites on Ca2+offers convenient explanation of the stimulation-coupled mob...
H. Yamamoto, T. Utsumi, M. Miyahara
Pharmacometrics   30 19-29   Jan 1985   [Refereed]
Interaction of Ricin and its Constituent Polypeptides with Dipalmitoyl Phosphatidyl Choline Vesicles
Biochemical and Biophysical Acta   772    1984   [Refereed]

Books etc

 
Molecular determinants of intracellular processing of human pro-tumor necrosis factor.
Membrane Ptoteins ; Structure, Function and Expression Control, Kyusyu Univ. Press-S. Karger AG.   1997   
Neutrophils and priming.Isolation of neutrophils/assay of O2- generation by cytochrome-C reductionn
Experimental protocols for reactive oxygen and nitrogen species.Oxford Univ.Press   2000   
Dictionary of Proteomics
Sep 2013   ISBN:4061538934

Conference Activities & Talks

 
Lipidation of Arabidopsis CPK6 promotes the plasma membrane targeting and the stomata closure mediated by 
activation of SLAC1 in Arabidopsis guard cells.
Saito S, Hamamoto S, Sato Y, Uozumi N, Hashimoto K, Kudla J, Utsumi T, Moriya K, Tozawa Y, Yamauchi S

International workshop on Plant Membrane Biology.   5 Jun 2016   

Teaching Experience