Takanori Nakamura

Profile Information

Affiliation: Professor, Faculty of Medicine, Kagawa University

Degree: 理学修士(九州大学)
理学博士(九州大学)

J-GLOBAL ID: 200901066758122947
researchmap Member ID: 1000039051

External link: http://www.med.kagawa-u.ac.jp/course/endo/

Research Interests

Research Areas

Research History

2002 - 2003

香川医科大学医学部医学科（生体分子医学講座・分子細胞機能学/講座再編のため）, 教授
2003

- 香川大学医学部医学科（生体分子医学講座・分子細胞機能学/大学統合のため）, 教授
1997 - 2002

Kagawa Medical University
1992 - 1997

The University of Tokushima
1997

徳島大学分子酵素学研究センター（BioRI共同利用実験施設）, 助教授
1991 - 1992

九州大学大学院農学研究課（遺伝子資源工学専攻）, 助手
1988 - 1991

理化学研究所, 国際フロンティアシステム研究員
1986 - 1988

日本学術振興会, 特別研究員

Education

- 1986

生物学, Graduate School, Division of Natural Science, Kyushu University
- 1986

生物学, 理学研究科, 大学院
- 1980

生物学, Faculty of Science, Kyushu University
- 1980

School of Sciences, Kyushu University

Committee Memberships

評議員, 日本生化学会

Awards

2008

日本生化学会JB論文賞

Papers

Galectin-9 induces atypical ubiquitination leading to cell death in PC-3 prostate cancer cells.

Itoh A, Nonaka Y, Ogawa T, Nakamura T, Nishi N

Glycobiology, 29(1) 22-35, Jan, 2019 Peer-reviewed
X-ray structure of a protease-resistant mutant form of human galectin-9 having two carbohydrate recognition domains with a metal-binding site

Hiromi Yoshida, Nozomu Nishi, Kenji Wada, Takanori Nakamura, Mitsuomi Hirashima, Naoyuki Kuwabara, Ryuichi Kato, Shigehiro Kamitori

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 490(4) 1287-1293, Sep, 2017 Peer-reviewed
Small leucine-rich repeat proteoglycans associated with mature insoluble elastin serve as binding sites for galectins

Aiko Itoh, Yasuhiro Nonaka, Takashi Ogawa, Takanori Nakamura, Nozomu Nishi

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 81(11) 2098-2104, 2017 Peer-reviewed
Galectin-4 expression is down-regulated in response to autophagy during differentiation of rat trophoblast cells

Tomohiro Arikawa, Shengjun Liao, Hiroki Shimada, Tomoki Inoue, Hiromi Sakata-Haga, Takanori Nakamura, Toshihisa Hatta, Hiroki Shoji

SCIENTIFIC REPORTS, 6 32248, Aug, 2016 Peer-reviewed
Cooperative Interactions of Oligosaccharide and Peptide Moieties of a Glycopeptide Derived from IgE with Galectin-9

Shin-ichi Nakakita, Aiko Itoh, Yukari Nakakita, Yasuhiro Nonaka, Takashi Ogawa, Takanori Nakamura, Nozomu Nishi

JOURNAL OF BIOLOGICAL CHEMISTRY, 291(2) 968-979, Jan, 2016 Peer-reviewed

Misc.

112

Crystal structure of a Xenopus laevis skin proto-type galectin, close to but distinct from galectin-1

Yasuhiro Nonaka, Takashi Ogawa, Hiromi Yoshida, Hiroki Shoji, Nozomu Nishi, Shigehiro Kamitori, Takanori Nakamura

GLYCOBIOLOGY, 25(7) 792-803, Jul, 2015 Peer-reviewed
Direct cytocidal effect of galectin-9 localized on collagen matrices on human immune cell lines

Youko Fukata, Aiko Itoh, Yasuhiro Nonaka, Takashi Ogawa, Takanori Nakamura, Osamu Matsushita, Nozomu Nishi

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1840(6) 1892-1901, Jun, 2014 Peer-reviewed
Significance of sugar chain recognition by galectins and its involvement in disease- associated glycosylation

Tomohiro Arikawa, Eriko Simamura, Hiroki Shimada, Takanori Nakamura, Toshihisa Hatta, Hiroki Shoji

CONGENITAL ANOMALIES, 54(2) 77-81, May, 2014 Peer-reviewed
Optimization of the inter-domain structure of galectin-9 for recombinant production

Aiko Itoh, Youko Fukata, Hiroshi Miyanaka, Yasuhiro Nonaka, Takashi Ogawa, Takanori Nakamura, Nozomu Nishi

(23) 920-925, Aug, 2013 Peer-reviewed
Self-association of the galectin-9 C-terminal domain via the opposite surface of the sugar-binding site

Yasuhiro Nonaka, Takashi Ogawa, Souichi Oomizu, Shin-ichi Nakakita, Nozomu Nishi, Shigehiro Kamitori, Mitsuomi Hirashima, Takanori Nakamura

JOURNAL OF BIOCHEMISTRY, 153(5) 463-471, May, 2013 Peer-reviewed
Self-association of the galectin-9 C-terminal domain via the opposite surface of the sugar-binding site

Yasuhiro Nonaka, Takashi Ogawa, Souichi Oomizu, Shin-ichi Nakakita, Nozomu Nishi, Shigehiro Kamitori, Mitsuomi Hirashima, Takanori Nakamura

JOURNAL OF BIOCHEMISTRY, 153(5) 463-471, May, 2013 Peer-reviewed
Expression pattern of Galectin-4 in rat placentation.

Arikawa T, Simamura E, Shimada H, Nishi N, Tatsuno T, Ishigaki Y, Tomosugi N, Yamashiro C, Hata T, Takegami T, Mogami H, Yamaguchi K, Nakamura T, Otani H, Hatta T, Shoji H

(33) 885-887, 2012 Peer-reviewed
The Gal beta-(syn)-gauche configuration is required for galectin-recognition disaccharides

Jun Iwaki, Hiroaki Tateno, Nozomu Nishi, Toshikazu Minamisawa, Sachiko Nakamura-Tsuruta, Yoko Itakura, Junko Kominami, Tadasu Urashima, Takanori Nakamura, Jun Hirabayashi

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1810(7) 643-651, Jul, 2011 Peer-reviewed
Tissue-Specific Expression of Fucosylated Glycosphingolipid Species in Rat Prostate

Hiroshi Miyanaka, Takanori Nakamura, Nozomu Nishi

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74(6) 1261-1266, Jun, 2010 Peer-reviewed
Expression pattern and role of Galectin1 during early mouse myogenesis

Hiroki Shoji, Louise Deltour, Takanori Nakamura, Shahragim Tajbakhsh, Francoise Poirier

DEVELOPMENT GROWTH & DIFFERENTIATION, 51(7) 607-615, Sep, 2009 Peer-reviewed
Structural analysis of the recognition mechanism of poly-N-acetyllactosamine by the human galectin-9 N-terminal carbohydrate recognition domain

Masamichi Nagae, Nozomu Nishi, Takeomi Murata, Taichi Usui, Takanori Nakamura, Soichi Wakatsuki, Ryuichi Kato

GLYCOBIOLOGY, 19(2) 112-117, Feb, 2009 Peer-reviewed
Desulfated galactosaminoglycans are potential ligands for galectins: Evidence from frontal affinity chromatography

Jun Iwaki, Toshikazu Minamisawa, Hiroaki Tateno, Junko Kominami, Kiyoshi Suzuki, Nozomu Nishi, Takanori Nakamura, Jun Hirabayashi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 373(2) 206-212, Aug, 2008 Peer-reviewed
ガレクチンと免疫調節

中村隆範, 西望, 東海林博樹, NAKAMURA, Takanori, NISHI, Nozomu, SHOJI, Hiroki

臨床検査, 52(8) 871-879, Aug, 2008
Transient up-regulation of a novel member of Spot 14 family in androgen-stimulated rat prostate

Nozomu Nishi, Hiroki Shoji, Hiroshi Miyanaka, Takanori Nakamura

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1780(7-8) 1004-1009, Jul, 2008 Peer-reviewed
Induction of cell adhesion by galectin-8 and its target molecules in Jurkat T-cells

Hitomi Yamamoto, Nozomu Nishi, Hiroki Shoji, Aiko Itoh, Liang-Hao Lu, Mitsuomi Hirashima, Takanori Nakamura

JOURNAL OF BIOCHEMISTRY, 143(3) 311-324, Mar, 2008 Peer-reviewed
Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E-2-producing polymorphonuclear leukocytes

Yuka Tsuboi, Hiroko Abe, Ryusuke Nakagawa, Souichi Oomizu, Kota Watanabe, Nozomu Nishi, Takanori Nakamura, Akira Yamauchi, Mitsuomi Hirashima

CLINICAL IMMUNOLOGY, 124(2) 221-233, Aug, 2007
Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E-2-producing polymorphonuclear leukocytes

Yuka Tsuboi, Hiroko Abe, Ryusuke Nakagawa, Souichi Oomizu, Kota Watanabe, Nozomu Nishi, Takanori Nakamura, Akira Yamauchi, Mitsuomi Hirashima

CLINICAL IMMUNOLOGY, 124(2) 221-233, Aug, 2007
Double-stranded RNA induces galectin-9 in vascular endothelial cells: Involvement of TLR3, PI3K, and IRF3 pathway

Tadaatsu Imaizumi, Hidemi Yoshida, Nozomu Nishi, Hiroshi Sashinami, Takanori Nakamura, Mitsuomi Hirashima, Chikara Ohyama, Ken Itoh, Kei Satoh

Glycobiology, 17(7) 12C-15C, Jul, 2007
Carbohydrate-recognition domains of galectin-9 are involved in intermolecular interaction with galectin-9 itself and other members of the galectin family

Nobumitsu Miyanishi, Nozomu Nishi, Hiroko Abe, Yumiko Kashio, Rika Shinonaga, Shin-ichi Nakakita, Wataru Sumiyoshi, Akira Yamauchi, Takanori Nakamura, Mitsuomi Hirashima, Jun Hirabayashi

GLYCOBIOLOGY, 17(4) 423-432, Apr, 2007
Carbohydrate-recognition domains of galectin-9 are involved in intermolecular interaction with galectin-9 itself and other members of the galectin family

Nobumitsu Miyanishi, Nozomu Nishi, Hiroko Abe, Yumiko Kashio, Rika Shinonaga, Shin-ichi Nakakita, Wataru Sumiyoshi, Akira Yamauchi, Takanori Nakamura, Mitsuomi Hirashima, Jun Hirabayashi

GLYCOBIOLOGY, 17(4) 423-432, Apr, 2007

Books and Other Publications

分子細胞生物学基礎実験法改訂第2版

南江堂, 2004
ガレクチンファミリーと発生および生体防御（生体の科学、51巻、p228-233）

（財）金原一郎記念医学医療振興財団/医学書院, 2000
The Role of Follistatin in Activin Signal Transduction (Inhibin, Activin, Follistatin)

Serono Symposia USA/ Springer-Verlag New York, Inc., 1997
The Role of Follistatin in Activin Signal Transduction (Inhibin, Activin, Follistatin)

Serono Symposia USA/ Springer-Verlag New York, Inc., 1997
Limulus Proclotting Enzyme

Methods in Enzymology Academic Press, 1993
Activins, Activin-Binding Protein(Follistatin)and Activin Receptor

Methods in Protein Sequence Analysis Plenum Press. New York, 1993
Limulus Proclotting Enzyme

Methods in Enzymology Academic Press, 1993
Activins, Activin-Binding Protein(Follistatin)and Activin Receptor

Methods in Protein Sequence Analysis Plenum Press. New York, 1993
Limulus Clotting Factor C : Lipopolysaccharide-Sensitive Serine Protease Zymogen

Methods in Enzymology Academic Press, 1993
Limulus Clotting Factor B

Methods in Enzymology Academic Pless, 1993
Limulus Clotting Factor C : Lipopolysaccharide-Sensitive Serine Protease Zymogen

Methods in Enzymology Academic Press, 1993
Limulus Clotting Factor B

Methods in Enzymology Academic Pless, 1993

Presentations

ガレクチン−９の細胞内移行がタンパク質分解システムに与える影響と細胞死誘導作用の関連

第90回日本生化学会大会（2017年度生命科学系学会合同年次大会/ConBio2017）, 2017
ガレクチン-1の糖鎖特異性および多量体構造とアポトーシス誘導活性の相関について

2017年度生命科学系学会合同年次大会, 2017
ヒトガレクチン-1とツメガエルガレクチン-Vaの糖鎖選択性を決める構造的要因について

第16回日本蛋白質科学会年会, 2016
エンドサイトーシスによるガレクチン−９の細胞内移行と細胞死誘導作用の関連

第89回日本生化学会大会, 2016
ヒトガレクチン-1とツメガエルガレクチン-Vaの比較による、ガレクチンの構造と機能についての解析

第89回日本生化学会大会, 2016
ツメガエル皮膚ガレクチンの構造・機能解析とgalectin-1との比較

第15回日本蛋白質科学会年会, 2015
ツメガエル由来の二種のプロト型ガレクチンついてのX線結晶構造解析

第１４回四国免疫フォーラム, 2015
ガレクチン９ー糖ペプチド相互作用のペプチドバックボーンによる増強

第88回日本生化学会大会第38回日本分子生物学会年会合同大会, 2015
ツメガエル消化管およびヒト大腸がん細胞におけるガレクチン-4の発現及び機能解析

第38回日本分子生物学会年会、第88回日本生化学会大会合同大会, 2015
ツメガエル皮膚ガレクチンの立体構造とアロステリックな挙動についての解析

第38回日本分子生物学会年会、第88回日本生化学会大会（合同大会）, 2015
アフリカツメガエルの皮膚および遍在型ガレクチンの立体構造解析

第14回日本蛋白質科学会年会, 2014
新規エラスチン結合タンパク質としてのガレクチン

第87回日本生化学会大会, 2014
アフリカツメガエル皮膚由来ガレクチンの立体構造と機能の解析

第87回日本生化学会大会, 2014
タンデムリピート型ガレクチン-9のNおよびC末ドメインの水溶液中での挙動の解析

第13回日本蛋白質科学会年会, 2013
ガレクチン９を利用した非拡散性局所免疫抑制剤

第86回日本生化学会大会, 2013
ガレクチン-9のN、C末端ドメインの構造およびリガンド相互作用についての解析

第86回日本生化学会大会, 2013
免疫調節蛋白質ガレクチン‐９のＮＭＲを用いた解析

第11回四国免疫フォーラム, 2012
マスト細胞の脱顆粒調節におけるIgE糖鎖の役割：ガレクチン９結合性糖鎖の同定とその構造解析

第85回日本生化学会大会, 2012
生産型ガレクチン９：組換え蛋白質生産に向けたドメイン間構造の最適化

第85回日本生化学会大会, 2012
タンデムリピート型ガレクチン-9の二つの糖結合ドメインについてのNMRを用いた解析

第85回日本生化学会大会, 2012

Professional Memberships

Works

ガレクチンの糖鎖結合性に関する研究

2004 - 2005

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Papers

Misc.

Books and Other Publications

Presentations

Professional Memberships

Works

Research Projects

Menu