The concept of minimal intervention dentistry has evolved as a consequence of our increased understanding of the caries process and the development of adhesive restorative materials. Recently, new concepts of treatments for dentin caries by use of adhesive resins and glass-ionomer cements have been proposed. However, new hard tissue, indicated as the result of applying calcium hydroxide or adhesive resins and/or sterilized by the mixed drugs, formed with a tunnel defect frequency present, running from the medicament interface to the pulp. These reports suggest the urgent necessity for us to the establishment of the biological dentin regeneration therapy like the Modified Sealed Restoration (MSR). In this review, we reported at first about "Resin adhesion to caries-infected dentin", and then "Dentin regeneration therapy with growth factor (CTGF)" and "In vivo dentin regeneration by adhesive resin containing EVA+C" and finally "Future approaches to establish the dentin regeneration therapy".