2007年7月
Effects of dose of recombinant human BMP-2 on bone formation at palatal sites in young and old rats
DENTAL MATERIALS JOURNAL
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- 巻
- 26
- 号
- 4
- 開始ページ
- 481
- 終了ページ
- 486
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.4012/dmj.26.481
- 出版者・発行元
- JAPANESE SOC DENTAL MATERIALS DEVICES
This study was designed to examine the effects of dose of recombinant human BMP-2 (rhBMP-2) on bone formation at palatal sites in 10-week-old (10w) and 70-week-old (70w) rats, when combined with a polylactate-polyglycolate copolymer/gelatine sponge (PGS).
New bone formation was observed at six weeks after implantation. In the 10w rats, thickness of new bone (TNB) increased as the dosage increased from 0 mu g to 4 mu g, and decreased significantly as the dosage increased from 8 mu g to 24 mu g. In contrast, in the 70w rats, TNB increased as the dosage increased from 0 mu g to 16 mu g, and did not significantly change as the dosage increased from 16 mu g to 24 lug.
These results suggest that the most effective dosage of rhBMP-2 for induction of bone formation varies according to age.
New bone formation was observed at six weeks after implantation. In the 10w rats, thickness of new bone (TNB) increased as the dosage increased from 0 mu g to 4 mu g, and decreased significantly as the dosage increased from 8 mu g to 24 mu g. In contrast, in the 70w rats, TNB increased as the dosage increased from 0 mu g to 16 mu g, and did not significantly change as the dosage increased from 16 mu g to 24 lug.
These results suggest that the most effective dosage of rhBMP-2 for induction of bone formation varies according to age.
- リンク情報
- ID情報
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- DOI : 10.4012/dmj.26.481
- ISSN : 0287-4547
- Web of Science ID : WOS:000249480700003