2008
Dentin Regeneration by Direct Pulp Capping using rhBMP-2
Journal of Oral Tissue Engineering
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- Volume
- 5
- Number
- 3
- First page
- 145
- Last page
- 149
- Language
- English
- Publishing type
- DOI
- 10.11223/jarde.5.145
- Publisher
- Japanese Association of Regenerative Dentistry
The purpose of this study was to evaluate the effect of direct pulp capping using recombinant human BMP-2 (rhBMP-2) on dentin regeneration. RhBMP-2 (1.0 mg/ml) was dissolved in alginate-based gel (AG). Cavities with the exposed pulp area were prepared of first molars in Wister rats. All cavities were divided into two groups: The exposed pulps were covered with AG contained rhBMP-2 (BMP group), and covered with AG alone (AG group). Then they were sealed with glass ionomer cement (Fuji IILC EM). The animals were sacrificed at 3 and 8 weeks after operation. In both groups, the covered materials were observed at 3 weeks after operation, while they had disappeared and the tertiary dentin formation was observed into the prepared cavity at 8 weeks after operation. Thickness of the tertiary dentin of BMP group was significantly higher than that of AG group (P<0.05). These results suggest that AG is effective scaffold and direct pulp capping using AG contains rhBMP-2 is capable of enhancing dentin regeneration.
- Link information
- ID information
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- DOI : 10.11223/jarde.5.145
- ISSN : 1348-9623
- CiNii Articles ID : 130004456598