Papers

Oct, 2005

Identification of Caspase-6 as A Candidate Tumor Suppressor Gene at 4q25 in Oral Cancer(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)

Journal of hard tissue biology
  • Shinno Yasuo
  • ,
  • Gunduz Mehmet
  • ,
  • Gunduz Esra
  • ,
  • Shimizu Kenji
  • ,
  • Yoshiyama Masahiro
  • ,
  • Yasuoka Akira
  • ,
  • Nagai Noriyuki

Volume
14
Number
2
First page
328
Last page
329
Language
English
Publishing type
DOI
10.2485/jhtb.14.328
Publisher
The Society of Hard Tissue Biology

We recently reported the frequent deletion of chromosome 4q25 region in oral squamous cell carcinoma and discussed the Caspase-6 as a possible tumor suppressor gene in this region due to its near location to this hot spot. We this time examined the role of Caspase-6 in oral cancers. mRNA expression level, protein localization and gene mutation of Caspase-6 were analyzed. Reverse-transcription-PCR analysis demonstrated decreased expression in 40% and equal expression in 30% of Caspase-6 mRNA of primary tumors as compared with that matched normal samples. cDNA sequencing analysis of Caspase-6 did not reveal any somatic mutation. Caspase-6 protein localization was in similar proportion with its mRNA expression. Failure of Caspase-6 response in tumor samples as compared to normal samples could suggest Caspase-6 as a candidate tumor suppressor gene in a subset of oral cancer.

Link information
DOI
https://doi.org/10.2485/jhtb.14.328
CiNii Articles
http://ci.nii.ac.jp/naid/110005853584
CiNii Books
http://ci.nii.ac.jp/ncid/AA11074332
URL
https://jlc.jst.go.jp/DN/JALC/00276722279?from=CiNii
URL
http://search.jamas.or.jp/link/ui/2007049584
ID information
  • DOI : 10.2485/jhtb.14.328
  • ISSN : 1341-7649
  • CiNii Articles ID : 110005853584
  • CiNii Books ID : AA11074332

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