Oct, 2005
Identification of Caspase-6 as A Candidate Tumor Suppressor Gene at 4q25 in Oral Cancer(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
Journal of hard tissue biology
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- Volume
- 14
- Number
- 2
- First page
- 328
- Last page
- 329
- Language
- English
- Publishing type
- DOI
- 10.2485/jhtb.14.328
- Publisher
- The Society of Hard Tissue Biology
We recently reported the frequent deletion of chromosome 4q25 region in oral squamous cell carcinoma and discussed the Caspase-6 as a possible tumor suppressor gene in this region due to its near location to this hot spot. We this time examined the role of Caspase-6 in oral cancers. mRNA expression level, protein localization and gene mutation of Caspase-6 were analyzed. Reverse-transcription-PCR analysis demonstrated decreased expression in 40% and equal expression in 30% of Caspase-6 mRNA of primary tumors as compared with that matched normal samples. cDNA sequencing analysis of Caspase-6 did not reveal any somatic mutation. Caspase-6 protein localization was in similar proportion with its mRNA expression. Failure of Caspase-6 response in tumor samples as compared to normal samples could suggest Caspase-6 as a candidate tumor suppressor gene in a subset of oral cancer.
- Link information
- ID information
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- DOI : 10.2485/jhtb.14.328
- ISSN : 1341-7649
- CiNii Articles ID : 110005853584
- CiNii Books ID : AA11074332