2008年1月
Inclusion body myositis associated with human T-lymphotropic virus-type I infection: Eleven patients from an endemic area in Japan
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- 巻
- 67
- 号
- 1
- 開始ページ
- 41
- 終了ページ
- 49
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1097/nen.0b013e31815f38b7
- 出版者・発行元
- LIPPINCOTT WILLIAMS & WILKINS
The objective of this study was to investigate the association of human T-lymphotropic virus-type I (HTLV-I) infection with sporadic inclusion body myositis in 11 patients from an endemic area in Japan. The clinical features were consistent with sporadic inclusion body myositis, and anti-HTLV-I antibodies were present in the sera of all patients. Their muscle biopsies showed the diagnostic features of inclusion body myositis, including endomysial T-cell infiltration, rimmed vacuoles, deposits of phosphorylated tau, and abnormal filaments in the nuclei and cytoplasm of the myofibers. The fibers expressed major histocompatibility complex class I antigens and were invaded by CD8(+) and CD4(+) cells. In a single human leukocyte antigen-A2-positive patient, in situ human leukocyte antigen-A*0201 / Tax11-19-pentamer staining showed pentamer-positive cells surrounding the muscle fibers. Double-immunogold silver staining and polymerase chain reaction in situ hybridization revealed that HTLV-I proviral DNA was localized on helper-inducer T cells, but not on muscle fibers. Human llymphotropic virus-type I proviral loads in peripheral blood mononuclear cells from each patient were similar to those in HTLV-I-associated myelopathy/tropical spastic paraparesis. This study suggests that HTLV-I infection may be one of the causes of sporadic inclusion body myositis, as has been reported in human immunodeficiency virus type-I infection.
- リンク情報
- ID情報
-
- DOI : 10.1097/nen.0b013e31815f38b7
- ISSN : 0022-3069
- Web of Science ID : WOS:000252198500004