Chemotherapy with 2g of tegafur suppository (Sunfural® rectal capsules) was performed in 20 cases with oral squamous cell carcinoma. The clinical and histological effects, blood level and side effects were examined. The results obtained were as follows
1) The overall response rate was 37.5% with 6 cases having a partial response (≥50% regression). 2) Histological grading of the primary tumor according to Shimosato et al. was from grade I to IVC. 3) Blood levels were examined in 6 cases, and the mean level of tegafur and 5-FU 4 h after administration of 1 g of tegafur suppository were 34.2 μg/ml and 80.1 ng/ml, respectively. 4) Side effects were observed in 72.2% of the cases. © 1988, JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY. All rights reserved.