論文

査読有り
2015年3月

Quantitative analysis of skeletal muscle mass in patients with rheumatic diseases under glucocorticoid therapy - Comparison among bioelectrical impedance analysis, computed tomography, and magnetic resonance imaging

MODERN RHEUMATOLOGY
  • Osamu Hosono
  • ,
  • Noritada Yoshikawa
  • ,
  • Noriaki Shimizu
  • ,
  • Shigeru Kiryu
  • ,
  • Masaaki Uehara
  • ,
  • Hiroshi Kobayashi
  • ,
  • Ryo Matsumiya
  • ,
  • Akiko Kuribara
  • ,
  • Takako Maruyama
  • ,
  • Hirotoshi Tanaka

25
2
開始ページ
257
終了ページ
263
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3109/14397595.2014.935078
出版者・発行元
SPRINGER

Objectives. To determine the availability of bioelectrical impedance analysis (BIA), computed tomography (CT), and magnetic resonance imaging (MRI) for measurement of skeletal muscle mass in patients with rheumatic diseases and quantitatively assess skeletal muscle loss after glucocorticoid (GC) treatment.
Methods. The data from 22 patients with rheumatic diseases were retrospectively obtained. The muscle mass of body segments was measured with a BIA device in terms of skeletal muscle mass index (SMI). Cross-sectional area (CSA) was obtained from CT and MRI scans at the mid-thigh level using the image analysis program. We further assessed the data of three different measurements before and after GC treatment in 7 patients with rheumatic diseases.
Results. SMI of whole body was significantly correlated with estimated muscle volume and mid-thigh muscle CSA with CT and MRI (p < 0.01). Significant correlations between SMI and mid-thigh muscle CSA of each leg were also found (p < 0.01). All the three measurements were negatively correlated with GC dosage (p < 0.01). Signifi cant decline in mid-thigh muscle CSA with CT and MRI was found after GC treatment in 7 patients (p < 0.02). Those patients showed significant decline in SMI of whole body after GC treatment, but not in SMI of each leg. On the other hand, significant correlations between mid-thigh muscle CSA with CT and MRI were found before and after GC treatment (p < 0.01).
Conclusions. GC-related skeletal muscle loss could be quantitatively assessed with BIA, CT, or MRI in patients with rheumatic diseases, and CT and MRI appeared to be more accurate than BIA.

リンク情報
DOI
https://doi.org/10.3109/14397595.2014.935078
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25496410
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000350545700015&DestApp=WOS_CPL
ID情報
  • DOI : 10.3109/14397595.2014.935078
  • ISSN : 1439-7595
  • eISSN : 1439-7609
  • PubMed ID : 25496410
  • Web of Science ID : WOS:000350545700015

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