1996年3月
Apolipoprotein E polymorphism and susceptibility to early- and late-onset sporadic Alzheimer's disease in Hokkaido, the northern part of Japan
NEUROSCIENCE LETTERS
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- 巻
- 206
- 号
- 1
- 開始ページ
- 17
- 終了ページ
- 20
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/0304-3940(96)12415-0
- 出版者・発行元
- ELSEVIER SCI IRELAND LTD
Apolipoprotein E (ApoE) phenotypes and corresponding allele frequencies were examined in 72 patients (50-90 years of age) with sporadic Alzheimer's disease (AD) and 83 elderly controls (61-96 years of age) in Hokkaido, the northern part of Japan. The frequency of the ApoE-epsilon 4, allele was significantly higher in the patients with either early-onset (age <65 years) AD (0.40) or late-onset AD (0.26) than in controls (0.07), while the patients developing AD before 50 years of age had no epsilon 4 allele. The mean age at onset of AD was significantly lower in the ApoE-epsilon 4 homozygotes compared to that in the patients with either one or no epsilon 4 allele (60.2, 71.3 and 70.3 years, respectively). Our results indicate that the ApoE-epsilon 4 allele is associated with susceptibility to Japanese sporadic AD developing after 50 years of age and homozygosity for the epsilon 4 allele shifts the onset to earlier age.
- リンク情報
- ID情報
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- DOI : 10.1016/0304-3940(96)12415-0
- ISSN : 0304-3940
- PubMed ID : 8848271
- Web of Science ID : WOS:A1996UB09100005