Fukamizu Akiyoshi

J-GLOBAL         Last updated: Oct 17, 2019 at 02:50
Fukamizu Akiyoshi
University of Tsukuba
Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA)
Job title

Research Areas



Faculty of Agriculture, University of Tsukuba
Graduate School, Division of Agriculture, University of Tsukuba

Committee Memberships

Nov 2013
Nov 2015

Published Papers

Nagano, Katsumasa; Kwon, Chulwon; Ishida, Junji; Hashimoto, Tatsuo; Kim, Jun-Dal; Kishikawa, Nana; Murao, Mei; Kimura, Kenjiro; Kasuya, Yoshitoshi; Kimura, Sadao; Chen, Yi-Ching; Tsuchimochi, Hirotsugu; Shirai, Mikiyasu; Pearson, James T; Fukamizu, Akiyoshi
Journal of biochemistry      Sep 2019   [Refereed]
The apelin receptor (APJ), a receptor for apelin and elabela/apela, induces vasodilation and vasoconstriction in blood vessels. However, the prolonged effects of increased APJ-mediated signaling, involving vasoconstriction, in smooth muscle cells ...
Murata, Kazuya;Lu, Weizhe;Hashimoto, Misuzu;Ono, Natsumi;Muratani, Masafumi;Nishikata, Kana;Kim, Jun-Dal;Ebihara, Shizufumi;Ishida, Junji;Fukamizu, Akiyoshi
iScience   8 200-213   Oct 2018
Protein arginine methyltransferase 1 (PRMT1) catalyzes the asymmetric dimethylation of arginine residues in proteins and methylation of various RNA-binding proteins and is associated with alternative splicing in vitro. Although PRMT1 has essential...
Hashimoto, Tatsuo; Kihara, Minoru; Ishida, Junji; Imai, Nozomi; Yoshida, Shin-ichiro; Toya, Yoshiyuki; Fukamizu, Akiyoshi; Kitamura, Hitoshi; Umemura, Satoshi
Arteriosclerosis, thrombosis, and vascular biology   26(6) 1267-1272   Jun 2006
[OBJECTIVE] Physiological roles of apelin and its specific receptor APJ signaling were investigated in vascular smooth muscle cells (VSMCs). The present study determined whether apelin activates myosin light chain (MLC), a major regulatory event i...
Pathophysiology of placentation abnormalities in pregnancy-induced hypertension
Furuya, Mitsuko; Ishida, Junji; Aoki, Ichiro; Fukamizu, Akiyoshi
Vascular health and risk management   4(6) 1301-1313   Apr 2008
During embryogenesis and development, the fetus obtains oxygen and nutrients from the mother through placental microcirculation. The placenta is a distinctive organ that develops and differentiates per se, and that organizes fetal growth and mater...
Cell type-dependent transactivation or repression of mesoderm-restricted basic helix-loop-helix protein, POD-1/Capsulin
Miyagishi, M;Hatta, M;Ohshima, T;Ishida, Junji;Fujii, R;Nakajima, T;Fukamizu, A
Mol. Cell. Biochem.   205(1-2) 141-147   Jan 2000
A family of basic-helix-loop-helix (bHLH) nuclear factors play important roles in controlling cell growth and differentiation as critical regulatory components in transcription. Here we describe molecular characterization of mesoderm-specific bHLH...
Lu, Weizhe; Kim, Jun-Dal; Tabara, Saori; Kwon, Chulwon; Mizukami, Hayase; Kimura, Keiji; Fukamizu, Akiyoshi
Biochemical and Biophysical Research Communications   514(4) 1185-1191   May 2019   [Refereed]
Protein arginine methyltransferase PRMT5 synthesizes the symmetric dimethylarginine in nuclear and cytoplasmic proteins such as histone H2A, H4 and several non-histone proteins that are required for a variety of biological processes. Currently, tw...
Freyer, Laina; Hsu, Chih-Wei; Nowotschin, Sonja; Pauli, Andrea; Ishida, Junji; Kuba, Keiji; Fukamizu, Akiyoshi; Schier, Alexander F; Hoodless, Pamela A; Dickinson, Mary E; Hadjantonakis, Anna-Katerina
Cell reports   20(9) 2116-2130   Aug 2017   [Refereed]
Apela (also known as Elabela, Ende, and Toddler) is a small signaling peptide that activates the G-protein-coupled receptor Aplnr to stimulate cell migration during zebrafish gastrulation. Here, using CRISPR/Cas9 to generate a null, reporter-expre...
Tanimoto, Keiji; Matsuzaki, Hitomi; Okamura, Eiichi; Ushiki, Aki; Fukamizu, Akiyoshi; Engel, James Douglas
PLoS ONE   14(2) e0203099   Apr 2019   [Refereed]
Long-range associations between enhancers and their target gene promoters have been shown to play critical roles in executing genome function. Recent variations of chromosome capture technology have revealed a comprehensive view of intra- and inte...
Hada, Kazumasa; Hirota, Keiko; Inanobe, Ai; Kako, Koichiro; Miyata, Mai; Araoi, Sho; Matsumoto, Masaki; Ohta, Reiya; Arisawa, Mitsuhiro; Daitoku, Hiroaki; Hanada, Toshikatsu; Fukamizu, Akiyoshi
The Journal of Biological Chemistry   294(9) 3091-3099   Jan 2019   [Refereed]
The tricarboxylic acid (TCA) cycle (or citric acid cycle) is responsible for the complete oxidation of acetyl-CoA and formation of intermediates required for ATP production and other anabolic pathways, such as amino acid synthesis. Here, we uncove...
Kako, Koichiro; Kim, Jun-Dal; Fukamizu, Akiyoshi
Journal of Biochemistry   165(1) 9-18   Jan 2019   [Refereed]
The central dogma of molecular biology explains the fundamental flow of genetic information for life. Although genome sequence (DNA) itself is a static chemical signature, it includes multiple layers of information composed of messenger RNA (mRNA)...

Books etc

深水,昭吉 (Part:Contributor, アルギニンメチル化とシグナル伝達)
Jun 2015   
蛋白質 核酸 酵素
深水,昭吉 (Part:Supervisor, 新しいアルギニンメチル化-リン酸化コード)
Jan 2010   
深水,昭吉 (Part:Supervisor, レニン・アンジオテンシン系遺伝子欠損マウス)
Oct 2009   
深水,昭吉 (Part:Supervisor, メチル化アルギニンを介したエピジェネティックな血圧制御)
May 2009   
深水,昭吉 (Part:Supervisor, FOXOファミリーの代謝・寿命調節機構とアルギニンメチル化クロストーク制御)
Apr 2009   

Conference Activities & Talks

Biochemical modification and protein functions linked to mitochondria:lysine acetylation and arginine methylation [Invited]
KSBMB International Conference 2019   2 Jun 2019   
A Protein is Multi-lingual:New Metablic Pathway of Phospholipid in the Brain [Invited]
2019 Gwanak Symposium   31 May 2019   
権哲源;中村夏奈子;田原早央莉;金;石田純治;深水, 昭吉
第40回日本妊娠高血圧学会学術集会   21 Sep 2019   
田原早央莉;金;森遥佳;陸偉哲;深水, 昭吉
第92回日本生化学会大会   19 Sep 2019   
In vivoスクリーニング系による新規ヒスチジンメチル基転移酵素の探索
林岳宏;大徳浩照;中島実咲;田島達也;加香孝一郎;深水, 昭吉
第92回日本生化学会大会   19 Sep 2019   
石田純治;金;霍思全;中島実咲;深水, 昭吉
第92回日本生化学会大会   19 Sep 2019   
福島寛乃;有本光江;加香孝一郎;深水, 昭吉;繁森英幸
日本農芸化学会関東支部2019年度大会   7 Sep 2019   
星川紗更;池本光志;有本光江;加香孝一郎;深水, 昭吉;繁森英幸
日本農芸化学会関東支部2019年度大会   7 Sep 2019   
田原早央莉;金;森遥佳;陸偉哲;深水, 昭吉
2019年度日本化学会関東支部例会   22 Jun 2019   
林岳宏;大徳浩照;中島実咲;加香孝一郎;深水, 昭吉
2019年度日本生化学会関東支部例会   22 Sep 2019   

Teaching Experience


Research Grants & Projects

Molecular Biology of Signal-development Co-activator CBP
Molecular Characterization of Transcription Factors on Blood Pressure
Molecular Characterization of Cellular Injury of Hypertensive Mice


特許第6399874号 : 化合物の抗炎症効果または免疫抑制効果を予測する方法
2015-12851 : 活性化白血球の除去方法
015-12850 : 細胞を分離・解析する方法
2014-190001   : 化合物の抗炎症効果または免疫抑制効果を予測する方法
深水昭吉;金俊達;大黒, 理勝