2003年5月
The VirR/VirS regulatory cascade affects transcription of plasmid-encoded putative virulence genes in Clostridium perfringens strain 13
FEMS MICROBIOLOGY LETTERS
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- 巻
- 222
- 号
- 1
- 開始ページ
- 137
- 終了ページ
- 141
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S0378-1097(03)00255-6
- 出版者・発行元
- ELSEVIER SCIENCE BV
We analyzed the transcriptional regulation of the putative virulence genes encoded on the plasmid pCP13 from Clostridium perfringens strain 13. The transcription of the beta2-toxin (cpb2) and possible collagen adhesin (cna) genes were regulated in both a positive and negative manner, respectively, by the two-component VirR/VirS system. The secondary regulator of the VirR/VirS system, VR-RNA, also affects the expression of both of these genes in the same fashion as the VirRN/VirS system. This indicates that the global regulatory cascade of the VirR/VirS system controls the expression of virulence genes located on the plasmid, as well as those found chromosomally in C. perfringens strain 13. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Microbiological Societies.
- リンク情報
- ID情報
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- DOI : 10.1016/S0378-1097(03)00255-6
- ISSN : 0378-1097
- Web of Science ID : WOS:000183115800019