2006年6月
Evaluation of a cefoxitin disk diffusion test for the detection of mecA-positive methicillin-resistant Staphylococcus saprophyticus
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
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- ,
- ,
- 巻
- 27
- 号
- 6
- 開始ページ
- 500
- 終了ページ
- 504
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.ijantimicag.2006.01.009
- 出版者・発行元
- ELSEVIER SCIENCE BV
In order to validate the current Clinical and Laboratory Standards Institute (CLSI) criteria for the detection of mecA-mediated resistance in Staphylococcus saprophyticus, 101 clinical isolates, including 8 mecA-positive isolates, were investigated. All the isolates were in the range of the resistant category for coagulase-negative staphylococci with the 1 mu g oxacillin disk diffusion method and agar dilution method, despite 93 isolates (92%) being mecA-negative. On the other hand, the 30 mu g cefoxitin disk diffusion method showed clearly distinguishable zone diameters between the mecA-positive and -negative isolates. However, four of the mecA-negative isolates that would be considered resistant were false positive, and the current interpretive criteria of the CLSI may thus require reconsideration. This study suggests that the cefoxitin disk diffusion method could be more suitable than the oxacillin disk diffusion method for detecting mecA-mediated resistance in S. saprophyticus. (c) 2006 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.ijantimicag.2006.01.009
- ISSN : 0924-8579
- Web of Science ID : WOS:000238624800006