We report on new attempt to investigate baryon interactions in lattice QCD. From the Bethe-Salpeter (BS) wave function, we have successfully extracted the nucleon-nucleon (NN) potentials in quenched QCD simulations, which reproduce qualitative features of modern NN potentials. The method has been extended to obtain the tensor potential as well as the central potential and also applied to the hyperon-nucleon (YN) interactions, in both quenched and full QCD. © 2010 American Institute of Physics.