Tomio Okamura

Profile Information

Affiliation: Professor, Undergraduate School of Medicine, Faculty of Medicine, Shiga University of Medical Science

Degree: 医学博士(大阪市立大学)

J-GLOBAL ID: 200901016160601339
researchmap Member ID: 1000049617

Research Interests

Research Areas

Life sciences / Pharmacology /

Research History

2013 - Present

Dean of Faculty, Shiga University of Medical Science
2013 - Present

Shiga University of Medical Science
1999 - Present

Shiga University of Medical Science
1999 - Present

Professor, Shiga University of Medical Science
1989 - 1999

Associate Professor, Shiga University of Medical Science
1989 - 1999

Shiga University of Medical Science
1982 - 1989

Research Assistant, Shiga University of Medical Science
1982 - 1989

Shiga University of Medical Science
1979 - 1982

Research Associate, Vanderbilt University
1979 - 1982

バンダービルト大学共同研究員

Education

1979 - Present

Pharmacology, Graduate School, Division of Medicine, Osaka City University
- 1979

Osaka City University
- 1975

med, Medical School, Osaka City University
- 1975

Faculty of Medicine, Osaka City University

Committee Memberships

2014 - Present

Japanese Society for Ocular Pharmacology, Head of Directors
2014 - Present

Japanese Pharmacological Society, Director
2014 - Present

理事長, 日本眼薬理学会
2014 - Present

理事, 日本薬理学会
2012 - Present

Japanese Society for Ocular Pharmacology, Director
2012 - Present

理事, 日本眼薬理学会
2007 - Present

Japanese Association of Cardiovascular Pharmacology, President
2007 - Present

会長, 日本循環薬理学会
2000 - Present

NO society of Japan, Director
2000 - Present

理事, 日本NO学会
1999 - Present

Japanese Society of Cardiovascular endocrinology and metabolism councilor
1999 - Present

Japanese Society for Circulation Research, councilor
1999 - Present

Japanese Society for Ocular Pharmacology councilor
1999 - Present

Japanese Association of Cardiovascular Pharmacology councilor
1999 - Present

幹事, 日本循環薬理学会
1999 - Present

評議員, 日本心脈管作動物質学会
1999 - Present

評議員, 日本眼薬理学会
1997 - Present

評議員, 日本心血管内分泌代謝学会
1991 - Present

Japanese society of Hypertension councilor
1991 - Present

評議員, 日本高血圧学会

Papers

260

Hyperhomocysteinemia impairs regional blood flow: involvements of endothelial and neuronal nitric oxide

Noboru Toda, Tomio Okamura

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 468(9) 1517-1525, Sep, 2016 Peer-reviewed
Cigarette smoking impairs nitric oxide-mediated cerebral blood flow increase: Implications for Alzheimer's disease

Noboru Toda, Tomio Okamura

JOURNAL OF PHARMACOLOGICAL SCIENCES, 131(4) 223-232, Aug, 2016 Peer-reviewed
Aging does not affect soluble guanylate cyclase redox state in mouse aortas

Takashi Shimosato, Masashi Tawa, Hirotaka Iwasaki, Takeshi Imamura, Tomio Okamura

PHYSIOLOGICAL REPORTS, 4(10), May, 2016 Peer-reviewed
MicroRNA-494 plays a role in fiber type-specific skeletal myogenesis in human induced pluripotent stem cells

Hirotaka Iwasaki, Takeshi Imamura, Katsutaro Morino, Takashi Shimosato, Masashi Tawa, Satoshi Ugi, Hidetoshi Sakurai, Hiroshi Maegawa, Tomio Okamura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 468(1-2) 208-213, Dec, 2015 Peer-reviewed
Duality of n-3 Polyunsaturated Fatty Acids on Mcp-1 Expression in Vascular Smooth Muscle: A Potential Role of 4-Hydroxy Hexenal

Kohji Nagayama, Katsutaro Morino, Osamu Sekine, Fumiyuki Nakagawa, Atsushi Ishikado, Hirotaka Iwasaki, Takashi Okada, Masashi Tawa, Daisuke Sato, Takeshi Imamura …

NUTRIENTS, 7(9) 8112-8126, Sep, 2015 Peer-reviewed
Recent advances in research on nitrergic nerve-mediated vasodilatation

Noboru Toda, Tomio Okamura

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 467(6) 1165-1178, Jun, 2015 Peer-reviewed
Vasorelaxing effects of the soluble guanylyl cyclase activator BAY 60-2770 in nitrate-tolerant monkey and canine coronary arteries

Masashi Tawa, Takashi Shimosato, Hirotaka Iwasaki, Takeshi Imamura, Tomio Okamura

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 388(3) 381-385, Mar, 2015 Peer-reviewed
Different Influences of Extracellular and Intracellular Superoxide on Relaxation Through the NO/sGC/cGMP Pathway in Isolated Rat Iliac Arteries

Masashi Tawa, Takashi Shimosato, Hirotaka Iwasaki, Takeshi Imamura, Tomio Okamura

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 65(2) 160-167, Feb, 2015 Peer-reviewed
Effects of hydrogen peroxide on relaxation through the NO/sGC/cGMP pathway in isolated rat iliac arteries

Masashi Tawa, Takashi Shimosato, Hirotaka Iwasaki, Takeshi Imamura, Tomio Okamura

FREE RADICAL RESEARCH, 49(12) 1479-1487, 2015 Peer-reviewed
A Noninvasive Metabolic Syndrome Model Using an Extremely Small Minipig, the Microminipig

Takehiro Yamaguchi, Takanori Yamazaki, Hiroaki Kawaguchi, Masashi Tawa, Yasuhiro Nakamura, Masayuki Shiota, Mayuko Osada-Oka, Akihide Tanimoto, Tomio Okamura, Katsuyuki Miura …

JOURNAL OF PHARMACOLOGICAL SCIENCES, 126(2) 168-171, Oct, 2014 Peer-reviewed
Soluble Guanylate Cyclase Redox State Under Hypoxia or Hypoxia/Reoxygenation in Isolated Monkey Coronary Arteries

Masashi Tawa, Ayman Geddawy, Takashi Shimosato, Hirotaka Iwasaki, Takeshi Imamura, Tomio Okamura

JOURNAL OF PHARMACOLOGICAL SCIENCES, 125(2) 169-175, Jun, 2014
Obesity-Induced Cerebral Hypoperfusion Derived from Endothelial Dysfunction: One of the Risk Factors for Alzheimer's Disease

Noboru Toda, Kazuhide Ayajiki, Tomio Okamura

CURRENT ALZHEIMER RESEARCH, 11(8) 733-744, 2014 Peer-reviewed
Effects of Atorvastatin, Amlodipine, and Their Combination on Vascular Dysfunction in Insulin-Resistant Rats

Tomio Okamura, Masashi Tawa, Ayman Geddawy, Takashi Shimosato, Hirotaka Iwasaki, Haruo Shintaku, Yuichi Yoshida, Masahiro Masada, Kazuya Shinozaki, Takeshi Imamura

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124(1) 76-85, Jan, 2014
Effects of Peroxynitrite on Relaxation through the NO/sGC/cGMP Pathway in Isolated Rat Iliac Arteries

Masashi Tawa, Takashi Shimosato, Hirotaka Iwasaki, Takeshi Imamura, Tomio Okamura

JOURNAL OF VASCULAR RESEARCH, 51(6) 439-446, 2014 Peer-reviewed
Obesity Impairs Vasodilatation and Blood Flow Increase Mediated by Endothelial Nitric Oxide: An Overview

Noboru Toda, Tomio Okamura

JOURNAL OF CLINICAL PHARMACOLOGY, 53(12) 1228-1239, Dec, 2013
Regulation of myometrial circulation and uterine vascular tone by constitutive nitric oxide

Noboru Toda, Hiroshi Toda, Tomio Okamura

EUROPEAN JOURNAL OF PHARMACOLOGY, 714(1-3) 414-423, Aug, 2013
4-Hydroxy Hexenal Derived from Docosahexaenoic Acid Protects Endothelial Cells via Nrf2 Activation

Atsushi Ishikado, Katsutaro Morino, Yoshihiko Nishio, Fumiyuki Nakagawa, Atsushi Mukose, Yoko Sono, Nagisa Yoshioka, Keiko Kondo, Osamu Sekine, Takeshi Yoshizaki …

PLOS ONE, 8(7) e69415, Jul, 2013
Influence of Hypoxia on Endothelium-Derived NO-Mediated Relaxation in Rat Carotid, Mesenteric and Iliac Arteries

Masashi Tawa, Takashi Shimosato, Ayman Geddawy, Takeshi Imamura, Tomio Okamura

PHARMACOLOGY, 91(5-6) 322-330, 2013
Neurogenic and Endothelial Nitric Oxide Regulates Blood Circulation in Lingual and Other Oral Tissues

Noboru Toda, Kazuhide Ayajiki, Tomio Okamura

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 60(1) 100-108, Jul, 2012
Different Effects of AT(1) Receptor Antagonist and ETA Receptor Antagonist on Ischemia-Induced Norepinephrine Release in Rat Hearts

Taiki Fukumoto, Masashi Tawa, Kento Kitada, Naoto Yamashita, Mamoru Ohkita, Tomio Okamura, Yasuo Matsumura

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 60(1) 55-60, Jul, 2012

Misc.

巻頭言

岡村富夫

眼薬理, 27(1) 1-2, 2013
第116回日本薬理学会近畿部会（研究室訪問）

岡村富夫

日薬理誌, 135 122, 2010
評価のむつかしさ

岡村富夫

日薬理誌, (132) 197-198, 2008
一酸化窒素（NO）

岡村富夫

細胞, 40(8) 24(318)-27(321), 2008
第７回日本NO学会学術集会

岡村富夫

血圧, 14(7) 62(740)-63(741), 2007
血管内皮機能障害-EDRF

岡村富夫

日本臨床： 2006年増刊高血圧（上）－最新の研究動向－, 64(増刊 5) 244-248, 2006
nＮＯSと脳血管拡張作用.抗血小板療法 ‐臨床での位置付けと有用性‐

安屋敷和秀, 岡村富夫

Mebio 別冊, 21(11) 134-142, 2005
インスリン抵抗性症候群とプテリジン代謝異常

篠崎一哉, 岡村富夫

日本ビタミン学会雑誌, 11 607-608, 2004
血管機能障害とNO-基礎-

岡村富夫

Brain Rescue, 7(4月) 20-21, 2004
NO産生機構

安屋敷和秀, 篠崎一哉, 岡村富夫

日本臨牀増刊：臨床分子内分泌学(1)?心血管内分泌代謝系(上), 62(9) 446-450, 2004
NOと病態はじめに

岡村富夫

医学のあゆみ, 204(9) 575-576, 2003
ＥＤとＮＯ

安屋敷和秀, 岡村富夫

医学のあゆみ, 204(9) 669-674, 2003
インスリン抵抗性状態におけるプテリジン代謝を介した内皮機能調節の重要性。

篠崎一哉, 西尾善彦, 柏木厚典, 岡村富夫

Therapeutic Research., 24(7) 1375-1382, 2003
NOと自律神経機能

岡村富夫

Clinical Neuroscience, 21(12) 1422-1425, 2003
血管内皮細胞ストレスとインスリン抵抗性

篠崎一哉, 岡村富夫

内分泌・糖尿病科, 14(6) 644-650, 2002
シンポジュウム1 内皮細胞と脈管疾患序文

岡村富夫

脈管学, 42(5) 289-289, 2002
研究室紹介3：滋賀医科大学薬理学講座

岡村富夫

血圧, 7(8) 78(872)-79(873), 2000
「血管系においてコリン系は重要か？」(116,206)を読んで

岡村富夫

日薬理誌, 116(5) 326-326, 2000
ストレスと血管

岡村富夫

循環plus, 3 5-6, 2000
NO作動性神経による血圧調節。特集－高血圧とNO －最近の進歩－

岡村富夫

血圧, 6(6) 14 (484)-18 (488), 1999

Books and Other Publications

血管機能異常とeNOSアンカップリング IN：脳血管シンポジウムⅠ

岡村富夫, 篠崎一哉

Mar, 2005
NO IN : 脳血管 2001

岡村富夫 (Role: Contributor)

金芳堂, May, 2001
An arachidonic acid metabolite(s) produced by the endothelial cytochrome P450 isoform, CYP3A4, relaxes the lingual artery of the monkey via K+ channel opening IN : EDHF 2000

Ayajiki K, Fujioka H, Toda N, Okada S, Minamiyama Y, Imaoka S, Funae Y, Okamura T

Taylor and Francis, 2001
消化管および子宮平滑筋作用 IN：全面改訂「カルシウム拮抗薬」

藤岡秀行, 岡村富夫

医薬ジャーナル社, 2001
自律神経のはたらきと自律神経失調 IN : 「元気で長生き:やまいの予防とくすり」

岡村富夫

メディカルレビュー社, 2001
Regulation of retinal arterial and arteriolar tone by nitric oxide derived from endothelium and perivascular nerve. IN : Nitric Oxide in the eye

Toda N, Toda M, Okamura T

Springer-Verlag, 2000
Modification by endothelial damage of the responses to vasodilators and nitrergic nerve stimulation in corpus cavernosum. IN : The Biology of Nitric Oxide Part 7

Okamura T, Ayajiki K, Fujioka H, Fujimiya M, Toda N

Portland Press, 2000
Distribution of nitric oxide synthase activity in human thyroid carcinoma-Analisis by high performance liquid chromatography. IN : The Biology of Nitric Oxide

Takeuchi E, Kitano H, KItajima K, Fujioka H, Okamura T, Toda N

Portland Press, 2000
Nitric oxide derived from perivascular nerves and endothelium. IN: Nitric oxide and the regulation of the peripheral circulation

Okamura T, Toda N

Birkhauser, 2000
AII受容体拮抗薬の動脈緊張およびコンプライアンスに対する作用 IN : AII受容体拮抗薬のすべて

岡村富夫

先端医学社, 2000
一酸化窒素（ＮＯ）による脳循環調節と脳神経外科 IN: 先端医療シリ-ズ６・脳神経外科・脳神経外科の最先端Ｎｏ．２ 21世紀の新領域とニューテクノロジー

安屋敷和秀, 田中俊樹, 岡村富夫, 戸田昇

先端医療技術研究所, 2000
血管拡張神経 IN : キーワード1999-2000高血圧

岡村富夫

先端医学社, 1999
血管内皮由来弛緩因子 IN : キーワード1999-2000高血圧

岡村富夫

先端医学社, 1999
中枢、末梢神経系とＮＯ IN : 脳血管１９９９

岡村富夫

金芳堂, 1999
ＮＯの治療への応用：ニトログリセリンからバイアグラまで IN :ＮＯの生理作用と疾患

岡村富夫

羊土社, 1999
Inhibition by hypoxia of nitroxidergic nerve function in canine cerebral arteries IN : The biology of Nitric Oxide Part6

Ayajiki K, Okamura T, Fujioka H, Toda N

Portland Press, 1998
Superoxide anion impairs endothelium-dependent vascular relaxation in insulin resistant rat aorta IN : The Biology of Nitric Oxide Part 6

Shinozaki K, Kashiwagi A, Okamura T, Nishio Y, Hidaka H, Ayajiki K, Toda N, Kikkawa R

Portland Press, 1998
Neurogenic nitric oxide and acetylcholine in the regulation of monkey ciliary arterial tone IN : The Biology of Nitric Oxide Part 6

Okamura T, Toda M, Ayajiki K, Toda N

Portland Press, 1998
アンジオテンシン受容体遮断薬 IN :「循環系治療薬の作用メカニズム」

岡村富夫

南江堂、, 1998
NOと高血圧。 IN : 「高血圧年報 1998-Review and Topics」

戸田昇, 岡村富夫

先端医学社, 1998

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