1994年3月
HISTOCHEMICAL-STUDY OF MITOCHONDRIAL-ENZYMES IN CEREBELLAR CORTEX OF MACULAR MUTANT MOUSE, A MODEL OF MENKES KINKY HAIR DISEASE
ACTA NEUROPATHOLOGICA
- ,
- ,
- 巻
- 87
- 号
- 3
- 開始ページ
- 313
- 終了ページ
- 316
- 記述言語
- 英語
- 掲載種別
- 記事・総説・解説・論説等(学術雑誌)
- 出版者・発行元
- SPRINGER VERLAG
The cerebellar Purkinje cells in the hemizygote of the macular mutant mouse contain numerous abnormal mitochondria which show a marked decrease in cytochrome c oxidase activity. Using histochemical methods we studied the activity of other mitochondrial enzymes, such as NADH diaphorase and succinic dehydrogenase, in the cerebellar cortex of this mutant mouse. Such activities were markedly increased in the Purkinje cells, especially in the soma and stem dendrite, from 10 days after birth in the hemizygote as compared with findings in normal littermates. These results were considered to be due to an increased number of abnormal mitochondria.
- リンク情報
- ID情報
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- ISSN : 0001-6322
- Web of Science ID : WOS:A1994MW73900012