Papers

Peer-reviewed
Apr, 2008

A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia

SCHIZOPHRENIA RESEARCH
  • Tsuyuka Ohtsuki
  • Minori Koga
  • Hiroki Ishiguro
  • Yasue Horiuchi
  • Makoto Arai
  • Kazuhiro Niizato
  • Masanari Itokawa
  • Toshiya Inada
  • Nakao Iwata
  • Shyuji Iritani
  • Norio Ozaki
  • Hiroshi Kunugi
  • Hiroshi Ujike
  • Yuichiro Watanabe
  • Toshiyuki Someya
  • Tadao Arinami
  • Display all

Volume
101
Number
1-3
First page
9
Last page
16
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1016/j.schres.2008.01.027
Publisher
ELSEVIER SCIENCE BV

Introduction: Glutamate dysfunction has been implicated in the pathophysiology of schizophrenia. The metabotropic glutamate receptors (rnGluRs) are G-protein-coupled receptors. GRM7, the gene that encodes mGluR7, is expressed in many regions of the human central nervous system. The GRM7 gene is located on human chromosome 3p26, which has been suggested by linkage analysis to contain a susceptibility locus for schizophrenia.
Methods: We screened for mutations in all exons, exori/intron junctions, and promoter regions of the GRM7 gene in Japanese patients with schizophrenia and evaluated associations between the detected polymorphisms and schizophrenia. We examined the influence of one polymorphism associated with schizophrenia on the expression of GRM7 by dual-luciferase assay in transfected cells.
Results: Twenty-five polymorphisms/mutations were detected in GRM7. Case-control analysis revealed a potential association of a synonymous polymorphism (371 T/C, rs3749380) in exon 1 with schizophrenia in our case-control study of 2293 Japanese patients with schizophrenia and 2382 Japanese control subjects (allelic p=0.009). Dual-luciferase assay revealed suppression of transcription activity by exon 1 containing this polymorphism and a statistically significant difference in the promoter activity between the T and C alleles.
Conclusions: Our results support the possible association of a GRM7 gene polymorphism with genetic susceptibility to schizophrenia. (C) 2008 Elsevier B.V All rights reserved.

Link information
DOI
https://doi.org/10.1016/j.schres.2008.01.027
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/18329248
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000256212200002&DestApp=WOS_CPL
ID information
  • DOI : 10.1016/j.schres.2008.01.027
  • ISSN : 0920-9964
  • Pubmed ID : 18329248
  • Web of Science ID : WOS:000256212200002

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