Feb, 2020
Non-Linear Pharmacokinetics of Atomoxetine in Adult Japanese Patients With ADHD.
Journal of attention disorders
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- Volume
- 24
- Number
- 3
- First page
- 490
- Last page
- 493
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1177/1087054716661235
Objective: The objective was to reveal the relationship between dose and concentration of atomoxetine. Method: Fifty-five blood samples of 33 patients with ADHD were examined using high-performance liquid chromatography. Results: The plasma concentrations were 53.2 ± 67.0, 298.0 ± 390.5, and 639.3 ± 831.9 ng/mL at doses of 40 mg, 80 mg, and 120 mg, and the concentration/dose were 1.33 ± 1.67, 3.73 ± 4.88, and 5.33 ± 6.93 ng/mL/mg, respectively. Statistical analyses revealed a significant correlation between the concentration and the dose of atomoxetine (p = .004), and a trending toward significance in the difference in the concentration/dose in the three dosage groups (p = .064). The concentration/dose at 40 and 80 + 120 mg/day were 1.33 ± 1.67 and 4.22 ± 5.53 ng/mL/mg, the latter was significantly higher than the former (p = .006), which suggested non-linear pharmacokinetics. Conclusion: Clinicians should carefully titrate in high dose atomoxetine treatment.
- Link information
- ID information
-
- DOI : 10.1177/1087054716661235
- Pubmed ID : 27474159