Papers

Peer-reviewed
Aug, 2003

A psychometrically derived impulsive trait related to a polymorphism in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) in a Japanese nonclinical population: Assessment by the Barratt Impulsiveness Scale (BIS)

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
  • K Sakado
  • ,
  • M Sakado
  • ,
  • T Muratake
  • ,
  • C Mundt
  • ,
  • T Someya

Volume
121B
Number
1
First page
71
Last page
75
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1002/ajmg.b.20063
Publisher
WILEY-LISS

Although a number of studies have shown that human impulsive traits are associated with indices of central serotonin function, few researchers have investigated the relationship between a polymorphism in the serotonin transporter gene-linked region (5-HTTLPR) and a psychometrically derived impulsive trait. We determined the 5-HTTLPR polymorphism in 123 employed Japanese male adults using the polymerase chain reaction. The distribution of allelic frequency was determined and also investigated the relationship of the 5-HTTLPR polymorphism to a impulsive trait as measured by the Barratt Impulsiveness Scale, 11th version (BIS-11). The distribution of allelic frequency was found to be almost identical to that previously reported in Japanese (the frequency for the long (L)/L, L/short (S), and S/S genotypes was: 3,28, and 68%, respectively). In a comparison between the genotype groups, the S/S genotype group significantly higher scored for the total BIS-11 and the subscale attentional impulsiveness than the L/S + L/L genotype group. These findings suggest that individuals with a homozygous S-allele may be more impulsive than those with the other genotype. (C) 2003 Wiley-Liss, Inc.

Link information
DOI
https://doi.org/10.1002/ajmg.b.20063
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000184548900011&DestApp=WOS_CPL
ID information
  • DOI : 10.1002/ajmg.b.20063
  • ISSN : 0148-7299
  • Web of Science ID : WOS:000184548900011

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