Papers

Peer-reviewed
Oct, 2006

Association study of a functional promoter polymorphism of the X-box binding protein 1 gene in Japanese patients with schizophrenia

PSYCHIATRY AND CLINICAL NEUROSCIENCES
  • Yuichiro Watanabe
  • ,
  • Naoki Fukui
  • ,
  • Tatsuyuki Muratake
  • ,
  • Hideki Amagane
  • ,
  • Naoshi Kaneko
  • ,
  • Ayako Nunokawa
  • ,
  • Toshiyuki Someya

Volume
60
Number
5
First page
633
Last page
635
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1111/j.1440-1819.2006.01570.x
Publisher
BLACKWELL PUBLISHING

The functional promoter polymorphism -116C/G of the X-box binding protein 1 (XBP1) gene was found to be associated with schizophrenia in Han Chinese and Japanese subjects, although contradictive negative findings were also reported in European populations. To confirm this association in a Japanese population, the authors conducted a case-control association study. There was no significant difference in both genotype and allele frequencies between the patients and control subjects, suggesting that the XBP1 -116C/G polymorphism might not confer increased susceptibility for schizophrenia in a Japanese population. However, further studies using a larger sample with detailed clinical data should be performed in several populations.

Link information
DOI
https://doi.org/10.1111/j.1440-1819.2006.01570.x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/16958950
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000240201100017&DestApp=WOS_CPL
ID information
  • DOI : 10.1111/j.1440-1819.2006.01570.x
  • ISSN : 1323-1316
  • Pubmed ID : 16958950
  • Web of Science ID : WOS:000240201100017

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