Oct, 2006
Association study of a functional promoter polymorphism of the X-box binding protein 1 gene in Japanese patients with schizophrenia
PSYCHIATRY AND CLINICAL NEUROSCIENCES
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- Volume
- 60
- Number
- 5
- First page
- 633
- Last page
- 635
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1111/j.1440-1819.2006.01570.x
- Publisher
- BLACKWELL PUBLISHING
The functional promoter polymorphism -116C/G of the X-box binding protein 1 (XBP1) gene was found to be associated with schizophrenia in Han Chinese and Japanese subjects, although contradictive negative findings were also reported in European populations. To confirm this association in a Japanese population, the authors conducted a case-control association study. There was no significant difference in both genotype and allele frequencies between the patients and control subjects, suggesting that the XBP1 -116C/G polymorphism might not confer increased susceptibility for schizophrenia in a Japanese population. However, further studies using a larger sample with detailed clinical data should be performed in several populations.
- Link information
- ID information
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- DOI : 10.1111/j.1440-1819.2006.01570.x
- ISSN : 1323-1316
- Pubmed ID : 16958950
- Web of Science ID : WOS:000240201100017