MISC

2003年11月

Distribution of mu receptors in the ventral respiratory group neurons; immunohistochemical and pharmacological studies in decerebrate cats

NEUROSCIENCE LETTERS
  • A Haji
  • ,
  • H Yamazaki
  • ,
  • Y Ohi
  • ,
  • R Takeda

351
1
開始ページ
37
終了ページ
40
記述言語
英語
掲載種別
DOI
10.1016/S0304-3940(03)00951-0
出版者・発行元
ELSEVIER SCI IRELAND LTD

Immunoreactivity for mu receptors was investigated in 21 bulbar respiratory neurons, individually identified by intracellular recording and labeling with neurobiotin. In 14 of these neurons, effects of iontophoresed morphine were examined. Morphine hyperpolarized the membrane and decreased spike discharges in 4/6 augmenting inspiratory (aug-I), 4/5 postinspiratory (post-I) and 3/3 augmenting expiratory (aug-E) neurons. It had no effect on two aug-I and one post-I neurons. Strong immunoreactivity for R receptor was detected in the soma and dendrites of 5/8 aug-I, 5/7 post-I and 6/6 aug-E neurons. In the remaining three aug-I and two post-I neurons that included cells unresponsive to morphine, weak immunoreactivity was detected only in the dendrites. These results demonstrated wide, but uneven, distribution of mu receptors in bulbar respiratory neurons and suggest their contribution to respiratory depression by opioids. (C) 2003 Elsevier Ireland Ltd. All rights reserved.


リンク情報
DOI
https://doi.org/10.1016/S0304-3940(03)00951-0
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000185863900010&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/S0304-3940(03)00951-0
  • ISSN : 0304-3940
  • Web of Science ID : WOS:000185863900010

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