MISC

2005年10月

Functional and morphological organization of the nucleus tractus solitarius in the fictive cough reflex of guinea pigs

NEUROSCIENCE RESEARCH
  • Y Ohi
  • ,
  • H Yamazaki
  • ,
  • R Takeda
  • ,
  • A Haji

53
2
開始ページ
201
終了ページ
209
記述言語
英語
掲載種別
DOI
10.1016/j.neures.2005.06.016
出版者・発行元
ELSEVIER IRELAND LTD

Projection of the superior laryngeal nerve (SLN) afferent fibers into the nucleus tractus solitarius (NTS) was investigated using a fluorescent tracer in guinea pigs. High density of fluorescence was detected in the ipsilateral NTS extending from 0.5 mm caudal to 1.2 mm rostral to the obex. At coronal slices, the fluorescent granules, lines and patches were located in the interstitial, medial and dorsal regions of NTS. Fluorescence was also found in the dorsal region of contralateral commissural NTS. Microstimulation of the rostral NTS, which corresponded to the region showing the strong fluorescence, induced an increase in the inspiratory discharge of phrenic nerve that was immediately followed by a large burst discharge of the iliohypogastric nerve in decerebrate, paralyzed and artificially ventilated guinea pigs. This serial response of the two nerves was identical to that induced by electrical stimulation of the SLN. Intravenous injection of codeine suppressed both NTS and SLN-induced responses. The SLN-induced response was inhibited by microinjection of codeine into the ipsilateral NTS and abolished by lesion of the ipsilateral NTS. These results suggest that the NTS has an integrative function in production of cough reflex and is possible sites of action of central antitussive agents. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.


リンク情報
DOI
https://doi.org/10.1016/j.neures.2005.06.016
CiNii Articles
http://ci.nii.ac.jp/naid/10017130474
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/16040147
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000232296800014&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.neures.2005.06.016
  • ISSN : 0168-0102
  • CiNii Articles ID : 10017130474
  • PubMed ID : 16040147
  • Web of Science ID : WOS:000232296800014

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