論文

査読有り
2009年2月

mu-Opioid and N-Methyl-D-aspartate Receptors Are Localized at Laryngeal Motoneurons of Guinea Pigs

BIOLOGICAL & PHARMACEUTICAL BULLETIN
  • Hiromi Yamazaki
  • ,
  • Yoshiaki Ohi
  • ,
  • Akira Haji

32
2
開始ページ
293
終了ページ
296
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1248/bpb.32.293
出版者・発行元
PHARMACEUTICAL SOC JAPAN

The glottic movement is important for generating efficient airflow in respiration and related reflexes such as coughing. The superior laryngeal nerve (SLN) innervates the cricothyroid muscle and regulates the glottic aperture. A total of 620 laryngeal motoneurons (LMNs) providing efferent fibers to the SLN were retrogradely identified with fluorescent wheat germ agglutinin (WGA) in 8 guinea pigs. The WGA-labeled cells were distributed in the ventrolateral part of nucleus ambiguus, extending 1.8-2.2 rum lateral to the midline, 0.8-1.2 mm from the ventral surface and 1.7-2.6 mm rostral to the obex. Double staining revealed that 28.4% of LMNs (44 out of 155 cells examined) were immunopositive to N-methyl-D-aspartate (NMDA) receptors and 29.2%, of LMNs (55 out of 185 cells) to mu-opioid receptors. The present study demonstrates phenotypic variation in the synaptic transmission to the LMNs in guinea pigs. These results suggest modulation of the glottic movement by mu-opioid and NMDA mechanisms.


リンク情報
DOI
https://doi.org/10.1248/bpb.32.293
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19182392
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000262838800024&DestApp=WOS_CPL
ID情報
  • DOI : 10.1248/bpb.32.293
  • ISSN : 0918-6158
  • PubMed ID : 19182392
  • Web of Science ID : WOS:000262838800024

エクスポート
BibTeX RIS