Toru Nabika

Profile Information

Degree: (BLANK)(*Shimane Medical University*)
(BLANK)

J-GLOBAL ID: 200901079399097332
researchmap Member ID: 1000050294

ラットの高血圧、脳卒中モデルを用いた高血圧、脳卒中感受性遺伝子の研究をしています。
近年は、ヒトにおける遺伝解析を経て、環境因子や社会的因子にも興味を持っており、疫学的研究にもかかわっています。特に島根県という地域の特性を活かした研究や予防活動ができないかと考えています。

Research Interests

Research Areas

Committee Memberships

2016 - 2017

編集委員、国際協力委員, 高血圧関連疾患モデル学会

Papers

187

Genotypes of Stim1 and the proximal region on chromosome 1 exert opposite effects on stroke susceptibility in stroke-prone spontaneously hypertensive rat.

Hiroki Ohara, Fumihiko Takeuchi, Norihiro Kato, Toru Nabika

Journal of hypertension, Sep 15, 2023
Associations between dairy consumption and the physical function in Japanese community-dwelling older adults: The Shimane CoHRE study

Ryo Miyazaki, Takafumi Abe, Naoki Sakane, Hitoshi Ando, Shozo Yano, Kenta Okuyama, Minoru Isomura, Masayuki Yamasaki, Toru Nabika

Geriatric Nursing, 53 19-24, Jul 3, 2023 Peer-reviewed
Association between flexibility activity and blood-pressure change among older adults in Japan: A 5-year longitudinal study.

Takafumi Abe, Kenta Okuyama, Masamitsu Kamada, Jun Kitayuguchi, Tsuyoshi Hamano, Hidefumi Waki, Toru Nabika, Minoru Isomura, Kristina Sundquist

Scandinavian journal of medicine & science in sports, May 11, 2023
Apolipoprotein E-depletion accelerates arterial fat deposition in the spontaneously hypertensive rat.

Hiroyuki Matsuo, Kohei Kawakami, Hiroki Ohara, Takehito Kaneko, Tomoji Mashimo, Takaya Yamada, Toru Nabika

Experimental animals, Apr 20, 2023
Neither Trimethylamine-N-Oxide nor Trimethyllysine Is Associated with Atherosclerosis: A Cross-Sectional Study in Older Japanese Adults

Jubo Bhuiya, Yoshitomo Notsu, Hironori Kobayashi, Abu zaffar shibly, Abdullah Md Sheikh, Ryota Okazaki, Kazuto Yamaguchi, Atsushi Nagai, Toru Nabika, Takafumi Abe …

Nutrients, 15(3), Feb, 2023
Changes in masticatory performance and the new onset of diabetes mellitus in older adults: a 5-year longitudinal study

Kazumichi Tominaga, Takafumi Abe, Yuichi Ando, Tsuyoshi Hamano, Minoru Isomura, Toru Nabika, Shozo Yano

DIABETOLOGY INTERNATIONAL, Dec, 2022
Genetic Modifications to Alter Blood Pressure Level.

Hiroki Ohara, Toru Nabika

Biomedicines, 10(8), Aug 1, 2022
Reduced masticatory performance and not using dentures are associated with hypertension in older adults with tooth loss: the Shimane CoHRE study

Takafumi Abe, Kazumichi Tominaga, Yuichi Ando, Tsuyoshi Hamano, Shozo Yano, Minoru Isomura, Toru Nabika

Hypertension Research, Jul 22, 2022
Milk Fermented with Mushrooms Prevents Stroke in the Stroke-Prone Spontaneously Hypertensive Rats Independently of Blood Pressure.

Zinat Mahal, Hiroyuki Matsuo, Hasan M Zahid, Yoshitomo Notsu, Hiroki Ohara, Kenji Okamoto, Toru Nabika

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 31(5) 106421-106421, May, 2022
Associations between physical frailty and living arrangements in Japanese older adults living in a rural remote island: The Shimane <scp>CoHRE</scp> study

Ryo Miyazaki, Takafumi Abe, Shozo Yano, Kenta Okuyama, Naoki Sakane, Hitoshi Ando, Minoru Isomura, Masayuki Yamasaki, Toru Nabika

Journal of General and Family Medicine, Apr 10, 2022
A 3-Mbp fragment on rat chromosome 1 affects susceptibility both to stroke and kidney injury under salt loading in the stroke-prone spontaneously hypertensive rat: a genetic approach using multiple congenic strains.

Mei Wang, Hiroki Ohara, Masahiro Egawa, Shohei Fukunaga, Hiroyuki Matsuo, Zhi-Ru Ge, Toru Nabika

Experimental animals, Mar 29, 2022
Combined association of oral and skeletal muscle health with type 2 diabetes mellitus among community-dwelling older adults in Japan: a cross-sectional study

Miwako Takeda, Takafumi Abe, Yuta Toyama, Kazumichi Tominaga, Shozo Yano, Toru Nabika, Masayuki Yamasaki

Journal of Rural Medicine, 17(2) 67-72, 2022
Car Driving Status and Living Arrangement Associated with Sarcopenia among Rural Japanese Older Adults: A Cross-Sectional Study.

Tsuyoshi Hamano, Takafumi Abe, Ryo Miyazaki, Kenta Okuyama, Kristina Sundquist, Toru Nabika

International journal of environmental research and public health, 19(1), Dec 31, 2021
Association between hilliness and walking speed in community-dwelling older Japanese adults: A cross-sectional study.

Takafumi Abe, Kenta Okuyama, Tsuyoshi Hamano, Masamitsu Kamada, Minoru Isomura, Toru Nabika, Ryo Miyazaki

Archives of gerontology and geriatrics, 97 104510-104510, Aug 26, 2021
Environmental Factors Affecting Cognitive Function among Community-Dwelling Older Adults: A Longitudinal Study

Atsushi Motohiro, Takafumi Abe, Kenta Okuyama, Keiichi Onoda, Tomoko Ito, Minoru Isomura, Toru Nabika, Shunichi Kumakura

International Journal of Environmental Research and Public Health, 18(16) 8528-8528, Aug 12, 2021
Effect of Multimorbidity on Fragility Fractures in Community-Dwelling Older Adults: Shimane CoHRE Study

Garu A, Shozo Yano, Abdullah Md Sheik, Aorigele Yu, Kenta Okuyama, Miwako Takeda, Kunie Kohno, Masayuki Yamasaki, Minoru Isomura, Toru Nabika …

Journal of Clinical Medicine, 10(15) 3225-3225, Jul 22, 2021
An association analysis between hypertension, dementia, and depression and the phases of pre-sarcopenia to sarcopenia: A cross-sectional analysis

Takeshi Endo, Kenju Akai, Tsunetaka Kijima, Shigetaka Kitahara, Takafumi Abe, Miwako Takeda, Toru Nabika, Shozo Yano, Minoru Isomura

PLOS ONE, 16(7) e0252784-e0252784, Jul 22, 2021
Relationship between Masticatory Function and Bone Mineral Density in Community-Dwelling Elderly: A Cross-Sectional Study.

Kumi Ikebuchi, Yuhei Matsuda, Mayu Takeda, Miwako Takeda, Takafumi Abe, Kazumichi Tominaga, Shozo Yano, Minoru Isomura, Toru Nabika, Takahiro Kanno

Healthcare (Basel, Switzerland), 9(7), Jul 5, 2021
Number of teeth and masticatory function are associated with sarcopenia and diabetes mellitus status among community-dwelling older adults: A Shimane CoHRE study

Takafumi Abe, Kazumichi Tominaga, Yuichi Ando, Yuta Toyama, Miwako Takeda, Masayuki Yamasaki, Kenta Okuyama, Tsuyoshi Hamano, Minoru Isomura, Toru Nabika …

PLOS ONE, 16(6) e0252625-e0252625, Jun 2, 2021
Assessing the Impact of a Hilly Environment on Depressive Symptoms among Community-Dwelling Older Adults in Japan: A Cross-Sectional Study

Takafumi Abe, Kenta Okuyama, Tsuyoshi Hamano, Miwako Takeda, Masayuki Yamasaki, Minoru Isomura, Kunihiko Nakano, Kristina Sundquist, Toru Nabika

International Journal of Environmental Research and Public Health, 18(9) 4520-4520, Apr 24, 2021

Misc.

184

多価不飽和脂肪酸合成酵素の遺伝子多型と精神疾患との関連

植田瑞美, 山崎雅之, 並河徹, 松崎健太郎, 住吉愛里, 橋本道男, 紫藤治, 片倉賢紀

脂質栄養学, 28(2) 148-148, Sep, 2019
The effect of neighborhood environment factors on physical activity and BMI among rural older adults : 10 years longitudinal cohort study

319-325, 2019
Additive Effect of Physical Activity and Sedentary Time on Depressive Symptoms in Rural Japanese Adults: A Cross-Sectional Study.

Abe T, Hamano T, Onoda K, Takeda M, Okuyama K, Yamasaki M, Isomura M, Nabika T

J Epidemiol., 29(6) 227-232, 2019
Evaluation of Pathological Association between Stroke-Related QTL and Salt-Induced Renal Injury in Stroke-Prone Spontaneously Hypertensive Rat.

Reza MF, Ngarashi D, Koike M, Misumi M, Ohara H, Nabika T

Biomed Res Int, 5049746, 2019
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV …

Neurology, 2019
Effect of geographic accessibility to primary care on treatment status of hypertension.

Kenta Okuyama, Kenju Akai, Tsunetaka Kijima, Takafumi Abe, Minoru Isomura, Toru Nabika

PloS one, 14(3) e0213098, 2019
Chronobiological characteristics of locomotor activity in congenic rats (SHRSPwch1.0) and their effects on arterial pressure.

Kawamura H, Mitsubayashi H, Ikeda K, Kawakami K, Nabika T

Clin Exp Hypertens, 6 1-9, 2019
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

Fumihiko Takeuchi, Masato Akiyama, Nana Matoba, Tomohiro Katsuya, Masahiro Nakatochi, Yasuharu Tabara, Akira Narita, Woei-Yuh Saw, Sanghoon Moon, Cassandra N Spracklen …

Nature communications, 9(1) 5052-5052, Nov 28, 2018
塩分摂取量と血圧上昇に関する正負の情報が高血圧罹患者と非罹患者の減塩価値に与える影響選択型実験法を用いたアンケート調査

赤井研樹, 青木恵子, 木島庸貴, 磯村実, 並河徹

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集, 7回 180-180, May, 2018
The Influence of Social Capital and Lifestyle Habits on Cognitive Functions Among People Living in Rural Area : Cross-sectional Study

Tomoko Ito, Kenta Okumura, Takafumi Abe, Toru Nabika

14 3-11, 2018
Further dissection of QTLs for salt-induced stroke and identification of candidate genes in the stroke-prone spontaneously hypertensive rat.

Kaoru Niiya, Hiroki Ohara, Masato Isono, Abdullah Md Sheikh, Hiroyuki Matsuo, Koichi Fujikawa, Minoru Isomura, Norihiro Kato, Toru Nabika

Scientific reports, 8(1) 9403-9403, 2018
Is familial risk for depression confounded by individual and familial socioeconomic factors and neighborhood environmental factors? A 7-year follow-up study in Sweden.

Hamano T, Li X, Lönn SL, Nabika T, Sundquist J, Sundquist K

Psychiatry Res, 266 30-35, 2018
Antihypertensive effect of γ-aminobutyric acid-enriched brown rice on spontaneously hypertensive rats

Kohei Kawakami, Kazuo Yamada, Takaya Yamada, Toru Nabika, Masato Nomura

Journal of Nutritional Science and Vitaminology, 64(1) 56-62, 2018
Development of the Japanese version of the general practice assessment questionnaire: measurement of patient experience and testing of data quality.

Tsunetaka Kijima, Kenju Akai, Akira Matsushita, Tsuyoshi Hamano, Keiichi Onoda, Shozo Yano, Toru Nabika, Yutaka Ishibashi, Shunichi Kumakura

BMC family practice, 19(1) 181-181, 2018
NADPH Oxidase-Related Pathophysiology in Experimental Models of Stroke

Hiroshi Yao, Tetsuro Ago, Takanari Kitazono, Toru Nabika

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(10), Oct, 2017
DEVELOPMENT OF A NEW MODEL FOR COMBINED ATHEROSCLEROSIS AND HYPERTENSION: APOE-KNOCKOUT SPONTANEOUSLY HYPERTENSIVE RAT

Hiroyuki Matsuo, Takehito Kaneko, Koichi Fujikawa, Hiroki Ohara, Tomoji Mashimo, Toru Nabika

ATHEROSCLEROSIS, 263 E86-E86, Aug, 2017
農業従事が健康寿命に関連する因子に及ぼす影響

山崎雅之, 武田美輪子, 矢野彰三, 木島庸貴, 磯村実, 和田孝一郎, 並河徹, 塩飽邦憲

共済エグザミナー通信, (42) 1-16, Apr, 2017
青魚摂取による赤血球膜不飽和脂肪酸組成変化ならびに精神神経機能改善作用の性差解析

松崎健太郎, 橋本道男, 田邊洋子, 住吉愛里, 並河徹, 紫藤治

脂質栄養学, 26(2) 210, 2017
PLASMA ARGININE/ADMA RATIO IS A SENSITIVE RISK MARKER FOR ATHEROSCLEROSIS: SHIMANE COHRE STUDY

S. Yano, Y. Notsu, A. Nagai, T. Nabika

ATHEROSCLEROSIS, 252 E64-E64, Sep, 2016
LIPOPROTEINS AND LIPID METABOLISM: HDL. ASSOCIATION OF HIGH-DENSITY LIPOPROTEIN SUBCLASSES WITH CAROTID INTIMA-MEDIA THICKNESS: SHIMANE COHRE STUDY

Y. Notsu, T. Nabika, S. Yano, A. Nagai

ATHEROSCLEROSIS, 252 E108-E108, Sep, 2016

Books and Other Publications

Hypertension, Heredity and Stroke

Nova Scientific Publishers, Inc, 2009
モデル動物の作製と維持

株式会社エル・アイ・シー, 2004 (ISBN: 4900487384)
The study of candidate genes in hypertension using tools of molecular biology and genetic epidemiology.

In : Dominiczak AF, Connell JMC, Soubrier F(eds) : Molecular Genetics of Hypertension. Bios Scientific PublishersLtd ; Oxford UK, 1999

Presentations

食塩感受性と血漿Asymmetric dimethylarginine レベルの関連

第３２回日本高血圧学会, 2009
心血管疾患のモデル動物：SHR and beyond

第３２回日本高血圧学会, 2009
腹腔内原発悪性ミュラー管混合腫瘍の1剖検例

第98回日本病理学会総会, 2009
胸腺嚢胞を合併し,多彩な組織像を呈する胸腺原発低分化型腺癌の一例

第98回日本病理学会総会, 2009
脳卒中関連QTL領域におけるmicrosatellite markerの多型検索

第56回日本実験動物学会総会, 2009
The Plasma Level of ARG/ADMA was Assoicated with the Microangiopathy-related Cerebral Damage (MARCD)

19th European Meeting on Hypertension, 2009
Circadian Variations in Arterial Pressure, Heart Rate and Locomotor Activity in Congenic Rats

36th International Congress of Physiological Sciences, 2009
メタボリックシンドロームモデル（SHR.Cg-Leprcp/NDｍｃｒ）を用いた水素豊富水の機能性の検証

第45回高血圧関連疾患モデル学会学術総会, 2009
SHRSP／Izmより良いコンジェニック・ラットの活動量と血圧の関係.

第45回高血圧関連疾患モデル学会学術総会, 2009
A small fragment on chromosome 1 controls urinary volume and norepinephrine excretion during cold stress.

第45回高血圧関連疾患モデル学会学術総会, 2009
Circadian Variations in Systolic Blood Pressure, Heart Rate and Locomotor Activity in Congenic Rats

63rd High Blood Pressure Research Conference, 2009
Lipoprotein-associated phospholipase A2活性に影響を与えるfunctional SNPの酸化LDLレベルと動脈硬化に対する効果-Shimane Study-

第31回日本高血圧学会総会, 2008
Genome-Wide Association Studyによるラクナ梗塞と高血圧の感受性遺伝子探索

第31回日本高血圧学会総会, 2008
コンジェニックラット（WKYpch1.0）における慢性的な環境ストレス負荷による血圧への影響

第31回日本高血圧学会総会, 2008
SHRSPをもとに作成したコンジェニックラットを用いた高血圧関連形質の解析

第31回日本高血圧学会総会, 2008
メタボリックシンドロームモデルラット（SHR/ｃｐ）に対する給餌制限の効果.

第44回高血圧関連疾患モデル学会学術総会, 2008
SHRSPにおける海馬CA1領域遅発性神経死の定量解析.

第44回高血圧関連疾患モデル学会学術総会, 2008
Ship2遺伝子多型はラット耐糖能に関与しない

第44回高血圧関連疾患モデル学会学術総会, 2008
脳卒中感受性領域のコンジェニックラットにおける表現形質検索.

第44回高血圧関連疾患モデル学会学術総会, 2008
浸潤性乳管癌を合併した糖尿病性乳腺症の一例.

第97回日本病理学会総会, 2008

Professional Memberships

高血圧関連疾患モデル学会

Research Projects

Effect of skeletal muscle-derived L-BAIBA on the prevention of hypertension

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Study of individual variation of aversive response to salty taste

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

NABIKA TORU
Regional development 2025 for elderly using geographic information systems

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

HAMANO Tsuyoshi
Is the Blood-Brain Barrier Weakened in Genetic Stroke Model Rats? A Study Utilizing in vitro Models System

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

YAMAGATA Kazuo, OOHARA Hirotaka
Elucidation of the interaction between genetic factors and social environmental factors aimed at preventing depression symptoms

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Takeda Miwako, HAMANO Tsuyoshi, NABIKA Toru
Journal Article A prospective study of social capital and depressive symptoms

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (A), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

HAMANO Tsuyoshi, TAKEDA Miwako, NABIKA Toru
Establishment of a genetic rat model for combined hypertension and atherosclerosis using the genome editing technology.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

NABIKA TORU
Elucidation of mechanisms of metabolic disorder-associated genes by the integration of genomic and non-genomic approaches

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Kato Norihiro, OKAMURA TADASHI, TAKEUCHI FUMIHIKO
Excess Salt Increases Infarct Size Produced by Photothrombotic Distal Middle Cerebral Artery Occlusion in Spontaneously Hypertensive Rats

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Yao Hiroshi, NABIKA Toru
Epidemiological Study of the relationship between Stress and IT products in Elementary School Students and Middle School Students: Toward the appropriate IT use

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2016

FUJITA Yasuyuki, NABIKA Toru, TANABE Tsuyoshi, INOUE Ken, AMANO Hiroki, MIURA Mikiko
Search for genes responsible for stress-induced hypertension in SHRSPcongenic rats.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

NABIKA Toru, HARADA Yuji, CUI Zh
Reconstruction of a genetic model rat of hypertension : Construction of double to four-fold congenic strains

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

CUI Zh, NABIKA Toru
Long-term follow-up population study of rural residents for prediction and prophylaxis of life-style related diseases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2010

YAMAGUCHI Syuhei, MASUDA Junichi, NABIKA Toru, SHIWAKU Kuninori
脳卒中の遺伝素因解明に向けた網羅的アプローチ

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2006 - 2007

加藤規弘, 小林祥泰, 並河徹, 柳内和幸
脳卒中の遺伝素因解明に向けた網羅的アプローチ

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2005 - 2006

加藤規弘, 柳内和幸, 小林祥泰, 並河徹
Genetic predisposition of cerebrovascular diseases and their prophylactic strategy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

MASUDA Junichi, KOBAYASI Syotai, NABIKA Toru
Dissection of blood pressure QTL using substrains of the spontaneously hypertensive rats ans congenic strains

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2004 - 2005

NABIKA Toru, IKEDA Kastumi, KATOU Norihiro
高血圧を中心とした生活習慣病の遺伝解析

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