MISC

2001年2月

The suppressing effect of the extract from Cassia nomame on clastogenicity and cytotoxicity of mitomycin C in CHO cells

JOURNAL OF HEALTH SCIENCE
  • S Kadowaki
  • ,
  • K Naitou
  • ,
  • Y Takahara
  • ,
  • K Yamamoto

47
1
開始ページ
86
終了ページ
88
記述言語
英語
掲載種別
DOI
10.1248/jhs.47.86
出版者・発行元
PHARMACEUTICAL SOC JAPAN

Chinese hamster ovary (CHO) K1 cells were treated with 2.5 muM Mitomycin C (MMC) for one hour and incubated in Ham's F12 medium containing 10% fetal bovine serum or in the medium supplemented with the extract from Cassia nomame pods, leaves and stems. The frequency of cells with chromosome aberrations was significantly lowered by the extract. Proliferation of CHO cells was suppressed by a l-hr MMC treatment, but the suppression was nullified by the presence of the extract. These findings suggest that the extract can prevent the physiological damage caused by MMC.


リンク情報
DOI
https://doi.org/10.1248/jhs.47.86
CiNii Articles
http://ci.nii.ac.jp/naid/110003641380
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000166839000017&DestApp=WOS_CPL

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