論文

査読有り
2017年2月

Human RAD 17 Polymorphism at Codon 546 Is Associated with the Risk of Colorectal Cancer.

Acta medica Okayama
  • Yukiko Yasuda
  • ,
  • Akiko Sakai
  • ,
  • Sachio Ito
  • ,
  • Kaori Sasai
  • ,
  • Hiromasa Yamamoto
  • ,
  • Nagahide Matsubara
  • ,
  • Mamoru Ouchida
  • ,
  • Hiroshi Katayama
  • ,
  • Kenji Shimizu

71
1
開始ページ
59
終了ページ
68
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.18926/AMO/54826
出版者・発行元
OKAYAMA UNIV MED SCHOOL

Human RAD17 acts as an activator of checkpoint signals in response to DNA damage. Here we evaluated the association of hRAD17 Leu546Arg (rs1045051), a missense single nucleotide polymorphism, with the risk of colorectal cancer (CRC) in relation to smoking and alcohol consumption habits in 212 CRC patients and 1,142 cancer-free controls in a case-control study conducted in Japan. The results showed that the hRAD17 Leu/Arg genotype compared to the Leu/Leu genotypes was significantly associated with the protective effect on CRC risk with the adjusted odds ratio (OR) of 0.68 [95% confidence interval (CI): 0.49-0.95, p=0.024], and the males with the Arg/Arg genotype had a greater risk of CRC compared to those with the Leu/Leu and Leu/Arg genotypes (OR=1.87, 95% CI 1.03-3.40, p=0.04). In stratified studies, the protective effect of the Leu/Arg genotype on CRC risk was markedly higher in the light smokers (< 20 pack years) (OR=0.61, 95% CI 0.40-0.94, p=0.024) and the rectal cancer patients (OR=0.49, 95% CI 0.31-0.78, p=0.003). The risk of the Arg/Arg genotype was associated with heavy smoking (>= 20 pack-years) (OR=2.24, 95% CI 1.09-4.61, p=0.03). These findings suggest that the genetic variant of hRAD17 Leu546Arg polymorphism has a significant effect on CRC susceptibility in Japanese.

リンク情報
DOI
https://doi.org/10.18926/AMO/54826
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28238011
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000396464200008&DestApp=WOS_CPL
ID情報
  • DOI : 10.18926/AMO/54826
  • ISSN : 0386-300X
  • PubMed ID : 28238011
  • Web of Science ID : WOS:000396464200008

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