Misc.

International journal
Jan, 2006

Histamine-induced vasodilation and vasoconstriction in the mesenteric resistance artery of the rat

EUROPEAN JOURNAL OF PHARMACOLOGY
  • H Jin
  • ,
  • T Koyama
  • ,
  • Y Hatanaka
  • ,
  • S Akiyama
  • ,
  • F Takayama
  • ,
  • H Kawasaki

Volume
529
Number
1-3
First page
136
Last page
144
Language
English
Publishing type
DOI
10.1016/j.ejphar.2005.10.060
Publisher
ELSEVIER SCIENCE BV

The present study was designed to examine the vascular response to histamine in rat perfused mesenteric vascular beds with active tone. In preparations with intact endothelium, perfusion of histamine (1 nM-100 mu M) produced a concentration-dependent vasodilation. Histamine-induced vasodilation was attenuated by L-NAME (nitric oxide (NO) synthase inhibitor, 100 mu M) and olopatadine (histamine H, receptor antagonist, 1 mu M) but not by laftitidine (histamine H-2 receptor antagonist, 1 mu M). Cold-storage denervation (4 degrees C for 72 h) of the preparation with intact endothelium attenuated the histamine-induced vasodilation. In preparations without endothelium, histamine at low concentrations (1-100 nM) produced only a small and rapid vasodilation, whereas histamine at concentrations higher than 1 mu M produced triphasic vascular responses: initial sharp vasodilation followed by transient vasoconstriction and subsequent gradual vasodilation. Lafutidine abolished only the histamine-induced initial vasodilation. Olopatadine abolished the histamine-induced second vasoconstriction and third vasodilation. Cold-storage denervation of the denuded preparation abolished the histamine-induced second vasoconstriction and third vasodilation. These findings suggest that histamine induced endothelium-dependent vasodilation via endothelium histamine H-1 receptors and endothelium-independent vasodilation via smooth muscle histamine H-2 receptors. It is also suggested that the histamine-induced endothelium-independent vasoconstriction and vasodilation are mediated by histamine H-1 receptors and perivascular nerves. (c) 2005 Elsevier B.V. All rights reserved.

Link information
DOI
https://doi.org/10.1016/j.ejphar.2005.10.060
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/16337938
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000234636400018&DestApp=WOS_CPL
ID information
  • DOI : 10.1016/j.ejphar.2005.10.060
  • ISSN : 0014-2999
  • Pubmed ID : 16337938
  • Web of Science ID : WOS:000234636400018

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