MISC

2010年8月

Effects of Docosahexaenoic Acid in an Experimental Rat Model of Nonalcoholic Steatohepatitis

JOURNAL OF OLEO SCIENCE
  • Fusako Takayama
  • ,
  • Kazuo Nakamoto
  • ,
  • Nagao Totani
  • ,
  • Tomoko Yamanushi
  • ,
  • Hideaki Kabuto
  • ,
  • Takao Kaneyuki
  • ,
  • Mitsumasa Mankura

59
8
開始ページ
407
終了ページ
414
記述言語
英語
掲載種別
DOI
10.5650/jos.59.407
出版者・発行元
JAPAN OIL CHEMISTS SOC

Docosahexaenoic acid (DHA) regulates the lipid metabolism and inflammation that is closely associated with oxidative stress. The present study investigated the effects of DHA on the development of nonalcoholic steatohepatitis (NASH). To induce fatty liver, rats were fed choline-deficient high-fat diets (CDHF). The rats were then divided into 4 groups treated over the subsequent 6 weeks as follows: control, CDHF, CDHF + oxidative stress (NASH), and NASH + DHA (1.0 g/kg, p.o.). Rats of the control group were fed NW chow diet only. NASH rats showed severe steatohepatitis and liver fibrosis. Treatment with DHA significantly decreased the n-6/n-3 ratio in the livers and increased plasma SOD like activity compared with NASH rats. In addition, DHA attenuated the liver fibrosis during NASH development. Therefore, a higher DHA ratio in the liver of NASH rats might regulate the inflammatory response through a low n-6 ratio and diminished oxidative stress, effectively inhibiting liver fibrosis during NASH progression. These results suggested that DHA is a novel functional food for the prevention of NASH.

リンク情報
DOI
https://doi.org/10.5650/jos.59.407
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20625232
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000280389900002&DestApp=WOS_CPL
ID情報
  • DOI : 10.5650/jos.59.407
  • ISSN : 1345-8957
  • eISSN : 1347-3352
  • PubMed ID : 20625232
  • Web of Science ID : WOS:000280389900002

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