2010 - 2012
Study of anti-metabolic syndrome effects of cholesteryl ester-n3 PUFA targeting for liver energy metabolism alteration in non-alcoholic steatohepatitis rats.
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
- Grant number
- 22500665
- Japan Grant Number (JGN)
- JP22500665
- Grant amount
-
- (Total)
- 4,290,000 Japanese Yen
- (Direct funding)
- 3,300,000 Japanese Yen
- (Indirect funding)
- 990,000 Japanese Yen
This study showed that DHA cholesteryl ester and EPA one were useful industrially, as both exerted higher effects to retard the NASH progress approximately 10 times than the respective ethyl ester. By evaluation system to reproduce NASH aggravation by choline deficient high fat diets and besides recurrent intermittent oxygen deficiency stress, it was exhibited that the efficacies resulted from relieving the decreased erythrocyte deformability and the persistent oxidative stress-inflammation.
- Link information
- ID information
-
- Grant number : 22500665
- Japan Grant Number (JGN) : JP22500665