Aug, 2009
Lipoprotein profiles in children with two common cholesteryl ester transfer protein gene mutations, D442G and I14A, during the first year of life
CLINICA CHIMICA ACTA
- Volume
- 406
- Number
- 1-2
- First page
- 52
- Last page
- 56
- Language
- English
- Publishing type
- DOI
- 10.1016/j.cca.2009.05.007
- Publisher
- ELSEVIER SCIENCE BV
Background: Hyperalphalipoproteinemia is associated with cholesteryl ester transfer protein (CETP) deficiency in adults but has unclear associations in children.
Methods: We measured lipoproteins in 19 heterozygotes (D442G, n = 17; I14A, n = 2), one D442G/I14A compound heterozygote, 13 non-affected siblings, and 30 healthy controls at birth, 3-4 months, and 12 months.
Results: CETP mass was 32-70% lower in heterozygotes than in controls throughout the year. Low-density lipoprotein-cholesterol (LDL-C) was lower in heterozygotes than in controls by 30, 20, and 15% at birth, 34 months, and 12 months, respectively. High-density lipoprotein-cholesterol (HDL-C) was similar among the groups at birth, but was 10% higher in heterozygotes compared with controls at 3-4 and 12 months. ApoE-rich HDL-C was similar between the two groups at birth, but was 50% higher in heterozygotes than in controls at 3-4 and 12 months. These lipoprotein profile characteristics were prominent in the compound heterozygote but were not found in non-affected siblings. In heterozygotes. CETP mass correlated positively with LDL-C but negatively with HDL-C at 3-4 and 12 months.
Conclusion: CETP is a determinant for LDL-C and HDL-C in CETP-deficient individuals in the first year of life. (C) 2009 Elsevier B.V. All rights reserved.
Methods: We measured lipoproteins in 19 heterozygotes (D442G, n = 17; I14A, n = 2), one D442G/I14A compound heterozygote, 13 non-affected siblings, and 30 healthy controls at birth, 3-4 months, and 12 months.
Results: CETP mass was 32-70% lower in heterozygotes than in controls throughout the year. Low-density lipoprotein-cholesterol (LDL-C) was lower in heterozygotes than in controls by 30, 20, and 15% at birth, 34 months, and 12 months, respectively. High-density lipoprotein-cholesterol (HDL-C) was similar among the groups at birth, but was 10% higher in heterozygotes compared with controls at 3-4 and 12 months. ApoE-rich HDL-C was similar between the two groups at birth, but was 50% higher in heterozygotes than in controls at 3-4 and 12 months. These lipoprotein profile characteristics were prominent in the compound heterozygote but were not found in non-affected siblings. In heterozygotes. CETP mass correlated positively with LDL-C but negatively with HDL-C at 3-4 and 12 months.
Conclusion: CETP is a determinant for LDL-C and HDL-C in CETP-deficient individuals in the first year of life. (C) 2009 Elsevier B.V. All rights reserved.
- Link information
- ID information
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- DOI : 10.1016/j.cca.2009.05.007
- ISSN : 0009-8981
- eISSN : 1873-3492
- Web of Science ID : WOS:000268923900011