2000年5月
Systemic inflammatory response syndrome and acute renal failure associated with Hemophilus influenzae septic meningitis
AMERICAN JOURNAL OF NEPHROLOGY
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- 巻
- 20
- 号
- 3
- 開始ページ
- 208
- 終了ページ
- 211
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- KARGER
Sepsis is often associated with a downward spiral through a spectrum of systemic inflammatory response syndrome (SIRS) culminating in organ failure and death. Here we present a 3-year-old girl with Hemophilus influenzae septic meningitis who developed SIRS and acute renal failure. In the initial stage, the patient showed uremia, cytopenia, disseminated intravascular coagulation, elevation of tissue enzyme and ferritin values, hemophagocytosis and overproduction of nitric oxide. The serum cytokine profile revealed increased levels of soluble interleukin (IL)-2 receptor, IL-6, IL-10 and tumor necrosis factor alpha. The patient responded positively to early and intensive interventions including antibiotics, repeated exchange transfusions, dexamethasone and high-dose gamma-globulin. The above laboratory abnormalities almost normalized with clinical improvement. We consider that SIRS was probably responsible for the sequence of events resulting in renal failure in this case, and suggest that renal failure should be included among the serious complications of SIRS associated with Hemophilus influenzae septic meningitis. Copyright (C) 2000 S. Karger AG, Basel.
- リンク情報
- ID情報
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- ISSN : 0250-8095
- Web of Science ID : WOS:000088296000007