2006年5月
Mitotic activity of multinucleated giant cells with glial fibrillary acidic protein immunoreactivity in glioblastomas: an immunohistochemical double labeling study
JOURNAL OF NEURO-ONCOLOGY
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- 巻
- 78
- 号
- 1
- 開始ページ
- 15
- 終了ページ
- 18
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1007/s11060-005-9067-z
- 出版者・発行元
- SPRINGER
To investigate the mitotic activity of multinucleated giant cells (MNGCs) with glial fibrillary acidic protein (GFAP) in glioblastomas, double immunohistochemical staining for GFAP and Ki67 was performed in formalin-fixed and paraffin-embedded specimens obtained from 12 primary glioblastomas with MNGCs including three giant cell glioblastomas. The Ki67 labeling index (LI:%) of GFAP+ tumor cells ranged from 0 to 5.6 (2.5 +/- 1.7, mean +/- standard deviation). The Ki67 LI of GFAP- tumor cells ranged from 18.6 to 35.9 (24.7 +/- 6.6). The Ki67 LI of GFAP+ cells was significantly lower than that of GFAP- cells (P < 0.0001). The number of Ki67+ GFAP- MNGCs ranged from 0 to 23 (8.6 +/- 8.2). The number of Ki67- GFAP+ MNGCs ranged from 0 to 15 (6.2 +/- 5.1). There was no significant difference between them (P=0.42). The Ki67 LI of GFAP+ MNGCs was 10.4 +/- 12.6. The Ki67 LI of GFAP- MNGCs was 45.9 +/- 29.9. The Ki67 LI of GFAP+ MNGCs was significantly lower than that of GFAP- MNGCs (P < 0.01). Our study suggested that MNGCs with mitotic capacity were not dominant and that GFAP+ MNGCs had little mitotic activity in glioblastomas. MNGCs identified in glioblastomas may develop via not only the proliferation of abnormal nuclei in a single tumor cell but also other processes.
- リンク情報
- ID情報
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- DOI : 10.1007/s11060-005-9067-z
- ISSN : 0167-594X
- Web of Science ID : WOS:000237796100003