MISC

2008年2月

Identification of an eosinophil chemotactic factor from anopheline mosquitoes as a chitinase family protein

PARASITOLOGY RESEARCH
  • Makoto Owhashi
  • ,
  • Masakazu Harada
  • ,
  • Setsuo Suguri
  • ,
  • Hiroshi Omae
  • ,
  • Akira Ishii

102
3
開始ページ
357
終了ページ
363
記述言語
英語
掲載種別
DOI
10.1007/s00436-007-0769-3
出版者・発行元
SPRINGER

Anopheline mosquitoes play an essential role in malaria transmission. The mosquito salivates copiously when probing for the location of a blood vessel. We found that the saliva of anopheline mosquitoes has chemotactic activity for naive eosinophils or neutrophils. The major eosinophil chemotactic component in saliva was shown to be one of the chitinase family proteins. A similar chitinase family protein was found also in the midgut of the anopheline mosquito. Production of antibodies to the chitinase family protein was generally observed in the sera of residents of a malaria endemic area. Both Plasmodium falciparum-infected and uninfected individuals had antibodies to chitinases. These results suggest that the chitinase family protein in mosquito saliva contributes to eliciting an inflammatory response of eosinophils in the host skin followed by antibody production in the host.

リンク情報
DOI
https://doi.org/10.1007/s00436-007-0769-3
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000252675800004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s00436-007-0769-3
  • ISSN : 0932-0113
  • eISSN : 1432-1955
  • Web of Science ID : WOS:000252675800004

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