MISC

2003年

Effect of different doses of cyanamide on striatal salsolinol formation after ethanol treatment

Legal Medicine
  • Mostofa Jamal
  • ,
  • Kiyoshi Ameno
  • ,
  • Setsuko Ameno
  • ,
  • Naoko Okada
  • ,
  • Iwao Ijiri

5
1
開始ページ
S79
終了ページ
S82
記述言語
英語
掲載種別
DOI
10.1016/S1344-6223(02)00083-4
出版者・発行元
Elsevier

To assess the dose-dependent effect of cyanamide (CY, a potent aldehyde dehydrogenase inhibitor) on salsolinol release in the striatum, rats were treated with CY (25, 50 and 100 mg/kg) plus ethanol (EtOH,1 g/kg) intraperitoneally. Striatal salsolinol was detected using in vivo microdialysis coupled with high-performance liquid chromatography with an electrochemical detector in free-moving rats, and blood acetaldehyde (AcH) and EtOH were detected using the head-space gas chromatographic method. With the increase in the doses of CY following EtOH, the peak concentrations of striatal salsolinol and blood AcH were increased significantly. Our study indicated that the magnitude of striatal salsolinol levels may depend on the concentration of blood AcH, and that there is a correlation between the blood AcH and striatal salsolinol. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/S1344-6223(02)00083-4
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/12935558
ID情報
  • DOI : 10.1016/S1344-6223(02)00083-4
  • ISSN : 1344-6223
  • PubMed ID : 12935558
  • SCOPUS ID : 0038077568

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