MISC

2003年5月

In vivo formation of salsolinol induced by high acetaldehyde concentration in rat striatum employing microdialysis

ALCOHOL AND ALCOHOLISM
  • M Jamal
  • ,
  • K Ameno
  • ,
  • T Kubota
  • ,
  • S Ameno
  • ,
  • Zhang, X
  • ,
  • M Kumihashi
  • ,
  • Ijiri, I

38
3
開始ページ
197
終了ページ
201
記述言語
英語
掲載種別
DOI
10.1093/alcalc/agg056
出版者・発行元
OXFORD UNIV PRESS

Aims: The in vivo formation of salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquionoline), an endogeneous condensation product of dopamine (DA) with acetaldehyde (AcH), was examined following the administration of cyanamide (CY) plus ethanol (EtOH) using microdialysis-high-performance liquid chromatography with electrochemical detection. Methods: After the insertion of a microdialysis probe into the striatum, rats were treated with CY (a potent inhibitor of aldehyde dehydrogenase, 50 mg/kg), 4-methylpyrazole (4-MP, a strong inhibitor of alcohol dehydrogenase, 82 mg/kg), and CY + 4-MP, followed 1 h later by EtOH (1 g/kg), CY and 4-MP only by intraperitoneal administration. Results: In the CY + EtOH group, salsolinol was detected in striatal dialysates and high AcH concentrations were found in the blood. The time course of changes in salsolinol concentrations correlated with blood AcH concentrations. In the other experimental groups, salsolinol in the dialysates and high AcH concentrations in the blood were not detected. Conclusions: These observations indicate that: (1) high AcH concentrations induce the formation of salsolinol in the rat striatum; (2) there is no effect of EtOH or AcH on striatal dialysate concentrations of DA and 5-hydroxytryptamine.

Web of Science ® 被引用回数 : 21

リンク情報
DOI
https://doi.org/10.1093/alcalc/agg056
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000182634900001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1093/alcalc/agg056
  • ISSN : 0735-0414
  • Web of Science ID : WOS:000182634900001

エクスポート
BibTeX RIS