二宮孝文 (Ninomiya Takafumi) - マイポータル

基本情報

所属: 札幌医科大学医学部医学科解剖学第一講座准教授

学位: 博士（医学）

J-GLOBAL ID: 200901083424800350
researchmap会員ID: 1000052938

研究キーワード

研究分野

経歴

2007年4月 - 現在

札幌医科大学, 医学部, 准教授
2002年9月 - 2007年3月

札幌医科大学, 医学部, 助教授
1994年3月 - 2002年8月

札幌医科大学, 医学部, 講師
1983年4月 - 1994年2月

札幌医科大学, 医学部, 助手
1979年4月 - 1983年3月

佐賀医科大学, 解剖学教室, 教務員

委員歴

2005年4月 - 現在

日本解剖学会, 評議員

論文

c-Jun N-terminal kinase inhibitor SP600125 enhances barrier function and elongation of human pancreatic cancer cell line HPAC in a Ca-switch model

Takumi Konno, Takafumi Ninomiya, Takayuki Kohno, Shin Kikuchi, Norimasa Sawada, Takashi Kojima

HISTOCHEMISTRY AND CELL BIOLOGY 143(5) 471-479 2015年5月査読有り
Staurosporine Induces Formation of Two Types of Extra-Long Cell Protrusions: Actin-Based Filaments and Microtubule-Based Shafts

Takayuki Kohno, Takafumi Ninomiya, Shin Kikuchi, Takumi Konno, Takashi Kojima

MOLECULAR PHARMACOLOGY 87(5) 815-824 2015年5月査読有り
Amphiphilic Gold Nanoparticles Displaying Flexible Bifurcated Ligands as a Carrier for siRNA Delivery into the Cell Cytosol

Kenichi Niikura, Kenya Kobayashi, Chie Takeuchi, Naoki Fujitani, Shuko Takahara, Takafumi Ninomiya, Kyoji Hagiwara, Hideyuki Mitomo, Yoshihiro Ito, Yoshihito Osada …

ACS APPLIED MATERIALS & INTERFACES 6(24) 22146-22154 2014年12月査読有り
Activated Hepatic Stellate Cells Are Dependent on Self-collagen, Cleaved by Membrane Type 1 Matrix Metalloproteinase for Their Growth

Naoko Kubo Birukawa, Kazuyuki Murase, Yasushi Sato, Akemi Kosaka, Akihiro Yoneda, Hiroki Nishita, Ryosuke Fujita, Miyuki Nishimura, Takafumi Ninomiya, Keiko Kajiwara …

JOURNAL OF BIOLOGICAL CHEMISTRY 289(29) 20209-20221 2014年7月査読有り
Enhanced cellular uptake of amphiphilic gold nanoparticles with ester functionality

Kenya Kobayashi, Kenichi Niikura, Chie Takeuchi, Shota Sekiguchi, Takafumi Ninomiya, Kyoji Hagiwara, Hideyuki Mitomo, Yoshihiro Ito, Yoshihito Osada, Kuniharu Ijiro

CHEMICAL COMMUNICATIONS 50(10) 1265-1267 2014年査読有り
Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano

Masayuki Someya, Takashi Kojima, Marie Ogawa, Takafumi Ninomiya, Kazuaki Nomura, Akira Takasawa, Masaki Murata, Satoshi Tanaka, Tsuyoshi Saito, Norimasa Sawada

CELL AND TISSUE RESEARCH 354(2) 481-494 2013年11月査読有り
Expression of tricellulin in epithelial cells and non-epithelial cells

Takashi Kojima, Takafumi Ninomiya, Takumi Konno, Takayuki Kohno, Masahiko Taniguchi, Norimasa Sawada

HISTOLOGY AND HISTOPATHOLOGY 28(11) 1383-1392 2013年11月査読有り
Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitro and in Vivo

Kenichi Niikura, Tatsuya Matsunaga, Tadaki Suzuki, Shintaro Kobayashi, Hiroki Yamaguchi, Yasuko Orba, Akira Kawaguchi, Hideki Hasegawa, Kiichi Kajino, Takafumi Ninomiya …

ACS NANO 7(5) 3926-3938 2013年5月査読有り
Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions

Akira Takasawa, Takashi Kojima, Takafumi Ninomiya, Mitsuhiro Tsujiwaki, Masaki Murata, Satoshi Tanaka, Norimasa Sawada

CELL AND TISSUE RESEARCH 351(1) 73-84 2013年1月査読有り
A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells.

Masaki T, Kojima T, Okabayashi T, Ogasawara N, Ohkuni T, Obata K, Takasawa A, Murata M, Tanaka S, Hirakawa S …

Molecular biology of the cell 22(13) 2144-2156 2011年7月査読有り
c-Jun N-Terminal Kinase Is Largely Involved in the Regulation of Tricellular Tight Junctions via Tricellulin in Human Pancreatic Duct Epithelial Cells

Takashi Kojima, Jun Fuchimoto, Hiroshi Yamaguchi, Tatsuya Ito, Akira Takasawa, Takafumi Ninomiya, Shin Kikuchi, Noriko Ogasawara, Tsuyoshi Ohkuni, Tomoyuki Masaki …

JOURNAL OF CELLULAR PHYSIOLOGY 225(3) 720-733 2010年12月査読有り
Tricellulin Is Expressed in Autotypic Tight Junctions of Peripheral Myelinating Schwann Cells

Shin Kikuchi, Takafumi Ninomiya, Haruyuki Tatsumi, Norimasa Sawada, Takashi Kojima

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 58(12) 1067-1073 2010年12月査読有り
The acid-sensing ion channel 2 (ASIC2) of ciliated cells in the developing rat nasal septum

Shin Kikuchi, Takafumi Ninomiya, Tomoyuki Kawamata, Noriko Ogasawara, Takashi Kojima, Nobutada Tachi, Haruyuki Tatsumi

ARCHIVES OF HISTOLOGY AND CYTOLOGY 73(2) 81-89 2010年査読有り
Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro

Tsuyoshi Ohkuni, Takashi Kojima, Noriko Ogasawara, Tomoyuki Masaki, Takafumi Ninomiya, Shin Kikuchi, Mitsuru Go, Ken-ichi Takano, Tetsuo Himi, Norimasa Sawada

MEDICAL MOLECULAR MORPHOLOGY 42(4) 204-211 2009年12月査読有り
Expression of ASIC2 in ciliated cells and stereociliated cells

Shin Kikuchi, Takafumi Ninomiya, Tomoyuki Kawamata, Haruyuki Tatsumi

CELL AND TISSUE RESEARCH 333(2) 217-224 2008年8月査読有り
Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro

Ken-ichi Takano, Takashi Kojima, Noriko Ogasawara, Mitsuru Go, Shin Kikuchi, Takafumi Ninomiya, Makoto Kurose, Jun-ichi Koizumi, Ryuta Kamekura, Masaki Murata …

JOURNAL OF MOLECULAR HISTOLOGY 39(3) 265-273 2008年6月査読有り
The change of grip strength in a patient with congenital myotonic dystrophy over a 4-year period

Shin Kikuchi, Naoki Kozuka, Eiji Uchida, Takafumi Ninomiya, Haruyuki Tatsumi, Hidekatsu Takeda, Nobutada Tachi

Journal of the Japanese Physical Therapy Association 11(1) 23-27 2008年査読有り
Induction of claudins in passaged hTERT-transfected human nasal epithelial cells with an extended life span

Makoto Kurose, Takashi Kojima, Jun-Ichi Koizumi, Ryuta Kamekura, Takafumi Ninomiya, Masaki Murata, Shingo Ichimiya, Makoto Osanai, Hideki Chiba, Tetsuo Himi …

CELL AND TISSUE RESEARCH 330(1) 63-74 2007年10月査読有り
Ex vivo large-scale generation of human platelets from cord blood CD34(+) cells

Takuya Matsunaga, Ikuta Tanaka, Masayoshi Kobune, Yutaka Kawano, Maki Tanaka, Kageaki Kuribayashi, Satoshi Iyama, Tsutomu Sato, Yasushi Sato, Rishu Takimoto …

STEM CELLS 24(12) 2877-2887 2006年12月査読有り
The nuclear receptor hepatocyte nuclear factor 4 alpha acts as a morphogen to induce the formation of microvilli

Hideki Chiba, Naoyuki Sakai, Masaki Murata, Makoto Osanai, Takafumi Ninomiya, Takashi Kojima, Norimasa Sawada

JOURNAL OF CELL BIOLOGY 175(6) 971-980 2006年12月査読有り

もっとみる

MISC

The correlation of morphological differentiation and development in dorsal root ganglion culture

Tiss. Cult. Res. Commun. 22 109-116 2003年
Colocalization of neurofilament proteins and vanilloid receptors in cultured dorsal root ganglion cells

Acta Anat Nippon 77 56-57 2002年
Influence of tooth-loss and concomitant masticatory alterations on cholinergic neurons in rats: Immunohistochemical and biochemical studies

H. Terasawa, T. Hirai, T. Ninomiya, Y. Ikeda, T. Ishijima, T. Yajima, N. Hamaue, Y. Nagase, Y. Kang, M. Minami

Neuroscience Research 43(4) 373-379 2002年
Chapter 3 Lower Limb

Gross Anatomy 4th edition 2001年
Characterization of binucleate neurons in cultures of rat dorsal root ganglion cells

Tiss Cult Res Commun 20 137-144 2001年
Involvement of TLCK-sensitive serine protease in colchicine-induced cell death of sympathetic neurons in culture

J. Neurosci Res 66 601-11 2001年
Nerve growth associated with the healing process of two types of palatal wounds in young rats: an immunohistochemical study

Sapporo Med. J 69 75-86 2000年
Sodium overload through voltage-dependent Na+ channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro

Brain Res Bull 51 345-55 2000年
Alteration of veratridine neurotoxicity in sympathetic neurons during development in vitro

Neuroreport 11 151-5 2000年
Effects of adrenergic stimulus on the activities of Ca2+ and K+ channels of dorsal root ganglion neurons in a neuropathic pain model

Y Honma, M Yamakage, T Ninomiya

BRAIN RESEARCH 832(1-2) 195-206 1999年6月
Direct evidence for the role of nitric oxide on the glutamate-induced neuronal death in cultured cortical neurons

M Yamauchi, K Omote, T Ninomiya

BRAIN RESEARCH 780(2) 253-259 1998年1月
Restricted expression of cell adhesion kinase-βin rat tissues

Am J. Pathol 150 267-81 1997年
Neuronal phenotypes in mouse dorsal root ganglion cell cultures: enrichment of substance P and calbindin D-28k expressing neurons in a defined medium.

Int J Dev Neurosci 12(2) 99-106 1994年
MOUSE FETAL TRISOMY-13 AND HYPOTROPHY OF THE SPINAL-CORD - EFFECT ON CALBINDIN-D-28K AND CALRETININ EXPRESSED BY NEURONS OF THE SPINAL-CORD AND DORSAL-ROOT GANGLIA

T NINOMIYA, M VUILLEMIN, WALTERBARAKAT, I, H WINKING, T PEXIEDER, B DROZ

NEUROSCIENCE 57(4) 1109-1120 1993年12月
An Additional Discovery of Salamanders, Salamandrella keyserlingii Dybowski, with no Blood Vessels in the Brain Parenchyma Except in the Olfactory Bulb

Kyozo Takahasm, Takafumi Ninomiya

Okajimas Folia Anatomica Japonica 68(6) 343-349 1992年
The neurite formation and morphological changes of dorsal root gangion cells

Mebio 8 110-115 1991年
New findings of the pseudounipolarization of neurites in rat dorsal root ganlion cells -Observations of dissociated cell culture using a VTR system-

Sapporo Med J. 60 391-398 1991年
Nucleosides influence the myelination of dorsal root ganglion cells in vitro; a quantitative comparison.

Brain Res 541 175-8 1991年
Myelin formation in rat dorsal root ganglion cultured in a serum-free medium: influence of various culture media on myelin formation.

Neurosci Res 6 115-22 1988年
Factors influencing myelin formation, with special reference to the effects of culture media

Tisuue Culture 14 360-365 1988年

もっとみる

書籍等出版物

コア解剖学

二宮孝文 (担当:分担執筆, 範囲:第3章下肢)

丸善 2001年

担当経験のある科目(授業)

所属学協会

共同研究・競争的資金等の研究課題

神経突起変性により誘導されるカスケードとその神経変性疾患モデルにおける解析

文部科学省科学研究費補助金(特定領域研究(C)) 特定領域研究(C) 2001年 - 2001年

小池達郎, 田中秀逸, 二宮孝文, 刀祢重信
変異Po cDNA導入培養ラツト末梢神経における髄鞘形成害

文部科学省科学研究費補助金(基盤研究(C)) 基盤研究(C) 1999年 - 2001年

舘延忠, 小塚直樹, 二宮孝文, 山下利春
神経突起変性により誘発される細胞内カスケードの解明

文部科学省科学研究費補助金(特定領域研究(C)) 特定領域研究(C) 2000年 - 2000年

小池達郎, 田中秀逸, 二宮孝文, 刀祢重信
加齢に伴う知覚神経節細胞の神経突起再形成の解析

文部科学省科学研究費補助金(基盤研究(C)) 基盤研究(C) 1997年 - 1998年

二宮孝文
侵害受容の末梢機序
知覚神経細胞の発生と老化