2011年11月
Islet-1 expression in thoracic spinal motor neurons in prenatal mouse
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
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- 巻
- 29
- 号
- 7
- 開始ページ
- 749
- 終了ページ
- 756
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.ijdevneu.2011.05.007
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
The LIM homeodomain protein Islet-1, an embryonic marker for motoneurons in the spinal cord, has been reported to be heterogeneously expressed among motoneuron groups in mouse. In the present study, we examined Islet-1 expression in the thoracic and rostral lumbar spinal cord in prenatal mice. In the thoracic spinal cord at embryonic day 12.5 (E12.5) and E13.5, strong Islet-1 immunoreactivity was observed in the lateral group of the ventral horn, whereas weaker immunoreactivity was observed in the ventral group. Strong Islet-1 immunoreactivity was also observed in the intermediolateral area and more medial part of the intermediate zone. In the rostral lumbar spinal cord at E12.5 and E13.5, strong Islet-1 immunoreactivity was observed in the lateral group of the ventral horn, and in the intermediolateral nucleus, whereas weaker immunoreactivity was observed in the ventral, and dorsolateral groups. At E14.5, the number of Islet-1 immunoreactive neurons was reduced in the spinal cord, but the distribution pattern was similar to that at E12.5 and E13.5. At E15.5, Islet-1 immunoreactivity was almost completely confined to the intermediolateral area. Some weakly immunoreactive neurons were observed in the ventral horn. The findings of the present study indicated that Islet-1 expression at embryonic stages differs among the motoneuron groups in the thoracic and rostral lumbar spinal cord. (C) 2011 ISDN. Published by Elsevier Ltd. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.ijdevneu.2011.05.007
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/21651972
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000296208400010&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80053569951&origin=inward
- ID情報
-
- DOI : 10.1016/j.ijdevneu.2011.05.007
- ISSN : 0736-5748
- PubMed ID : 21651972
- SCOPUS ID : 80053569951
- Web of Science ID : WOS:000296208400010