OHNO Shigeo

Last updated: Apr 24, 2018 at 21:42

Name	OHNO Shigeo
E-mail	ohnosmed.yokohama-cu.ac.jp
Affiliation	Yokohama City University
Job title	Professor
ORCID ID	0000-0002-1294-5269

Research Interests

aPKC(6) , ASIP(1) , PAR-3(5) , PAR-6(1) , C. elegans(39) , asymmetric division(2) , polarity(8) , epitheliumnonsense mutation(1) , mRNA degradation(2) , mRNA surveillance(2) , P53(59) , protein kinase(21) , PIK remated protein kinase(1) , RNA helicase(1) , ATPase(11)

Research Areas

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Basic medicine / Experimental pathology /
Basic medicine / Pathological medical chemistry /
Basic medicine / General medical chemistry /
Biological Science / Developmental biology /
Biological Science / Cell biology /

Academic & Professional Experience

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May 1991

Today

Professor, Molecular Biology, Yokohama City University School of Medicine

Apr 1983

Apr 1991

Research Scientist, Molecular Biology, Tokyo Metropolitan Institute of Medical Science

Education

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1980

Graduate School, Division of Natural Science, The University of Tokyo

1975

Faculty of Liberal Arts, The University of Tokyo

Published Papers

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Aberrant Expression of the Cell Polarity Regulator aPKC lambda/iota is Associated With Disease Progression in Cervical Intraepithelial Neoplasia (CIN): A Possible Marker for Predicting CIN Prognosis

Mizushima Taichi, Asai-Sato Mikiko, Akimoto Kazunori, Nagashima Yoji, Taguri Masataka, Sasaki Kazunori, Nakaya Masa-aki, Asano Ryoko, Tokinaga Aya, Kiyono Tohru, Hirahara Fumiki, Ohno Shigeo, Miyagi Etsuko

International Journal of Gynecological Pathology 35(2) 106-117 2016 [Refereed]

Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8+T Lymphocyte Fates

Metz Patrick J, Lopez Justine, Kim Stephanie H, Akimoto Kazunori, Ohno Shigeo, Chang John T.

Scientific Reports 6 2016 [Refereed]

Aberrant Activation of Atypical Protein Kinase C in Carbon Tetrachloride-Induced Oxidative Stress Provokes a Disturbance of Cell Polarity and Sealing of Bile Canalicular Lumen

Horikoshi Yosuke, Kitatani Kanae, Toriumi Kentaro, Fukunishi Nahoko, Itoh Yoshiko, Nakamura Naoya, Ohno Shigeo, Matsura Tatsuya, Takekoshi Susumu

American Journal of Pathology 185(4) 958-968 2015 [Refereed]

Atypical Protein Kinase C Isoform, aPKC lambda, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence

Osada Shin-Ichi, Minematsu Naoko, Oda Fumino, Akimoto Kazunori, Kawana Seiji, Ohno Shigeo

Journal of Investigative Dermatology 135(11) 2584-2592 2015 [Refereed]

Regulation of epithelial cell polarity by PAR-3 depends on Girdin transcription and Girdin-G alpha i3 signaling

Sasaki Kazunori, Kakuwa Taku, Akimoto Kazunori, Koga Hisashi, Ohno Shigeo

Journal of Cell Science 128(13) 2244-2258 2015 [Refereed]

Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex

Yamashita Kazunari, Ide Mariko, Furukawa Kana T, Suzuki Atsushi, Hirano Hisashi, Ohno Shigeo

Molecular Biology of the Cell 26(13) 2426-2438 2015 [Refereed]

An apico-basal cell polarity protein aPKC lambda is essential for the hair follicle cycling and hair follicle stem cell quiescence

Osada S, Minematsu N, Oda F, Akimoto K, Kawana S, Ohno S.

Journal of Investigative Dermatology 134 S66 2014 [Refereed]

Colorectal laterally spreading tumors show characteristic expression of cell polarity factors, including atypical protein kinase C lambda/iota, E-cadherin, beta-catenin and basement membrane component

Ichikawa Yasushi, Nagashima Yoji, Morioka Kaori, Akimoto Kazunori, Kojima Yasuyuki, Ishikawa Takashi, Goto Ayumu, Kobayashi Noritoshi, Watanabe Kazuteru, Ota Mitsuyoshi, Fujii Shoichi, Kawamata Mayumi, Takagawa Ryo, Kunizaki Chikara, Takahashi Hirokazu, Nakajima Atsushi, Maeda Shin, Shimada Hiroshi, Inayama Yoshiaki, Ohno Shigeo, Endo Itaru

Oncology Letters 8(3) 977-984 2014 [Refereed]

Structures of SMG1-UPFs Complexes: SMG1 Contributes to Regulate UPF2-Dependent Activation of UPF1 in NMD

Melero Roberto, Uchiyama Akiko, Castano Raquel, Kataoka Naoyuki, Kurosawa Hitomi, Ohno Shigeo, Yamashita Akio, Llorca Oscar

Structure 22(8) 1105-1119 2014 [Refereed]

The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions

Kudoh Ayumi, Takahama Shoukichi, Sawasaki Tatsuya, Ode Hirotaka, Yokoyama Masaru, Okayama Akiko, Ishikawa Akiyo, Miyakawa Kei, Matsunaga Satoko, Kimura Hirokazu, Sugiura Wataru, Sato Hironori, Hirano Hisashi, Ohno Shigeo, Yamamoto Naoki, Ryo Akihide

Retrovirology 11 2014 [Refereed]

The interaction of Kinesin-1 with its adaptor protein JIP1 can be regulated via proteins binding to the JIP1-PTB domain

Satake T, Otsuki K, Banba Y, Suenaga J, Hirano H, Yamanaka Y, Ohno S, Hirai S.-I.

BMC Cell Biology 2013 [Refereed]

Spatial regulation of VEGF receptor endocytosis in angiogenesis

Nakayama M, Nakayama A, van Lessen M, Yamamoto H, Hoffmann S, Drexler H.C.A, Itoh N, Hirose T, Breier G, Vestweber D, Cooper J.A, Ohno S, Kaibuchi K, Adams R.H.

Nature Cell Biology 2013 [Refereed]

High expression of KIBRA in low atypical protein kinase C-expressing gastric cancer correlates with lymphatic invasion and poor prognosis

Yoshihama Y, Izumisawa Y, Akimoto K, Satoh Y, Mizushima T, Satoh K, Chida K, Takagawa R, Akiyama H, Ichikawa Y, Kunisaki C, Inayama Y, Endo I, Nagashima Y, Ohno S.

Cancer Science 104(2) 259-265 2013 [Refereed]

The KIBRA-aPKC connection: A potential regulator of membrane trafficking and cell polarity

Yoshihama Y, Chida K, Ohno S.

Communicative and Integrative Biology 5(2) 146-151 2012 [Refereed]

Regulation of the alternative splicing of sarcoplasmic reticulum Ca 2+-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway

Zhao Y, Koebis M, Suo S, Ohno S, Ishiura S.

Biochemical and Biophysical Research Communications 423(2) 212-217 2012 [Refereed]

PAR-1/MARK: A kinase essential for maintaining the dynamic state of microtubules

Hayashi K, Suzuki A, Ohno S.

Cell Structure and Function 37(1) 21-25 2012 [Refereed]

N-and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

Okada-Katsuhata Y, Yamashita A, Kutsuzawa K, Izumi N, Hirahara F, Ohno S.

Nucleic Acids Research 40(3) 1251-1266 2012 [Refereed]

Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2

Izumi N, Yamashita A, Ohno S.

Nucleus 3(1) 29-43 2012 [Refereed]

Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex

Izumi N, Yamashita A, Hirano H, Ohno S.

Cancer Science 103(1) 50-57 2012 [Refereed]

Analysis of interferon-beta mRNA stability control after poly(I:C) stimulation using RNA metabolic labeling by ethynyluridine

Abe K, Ishigami T, Shyu A.-B, Ohno S, Umemura S, Yamashita A.

Biochemical and Biophysical Research Communications 428(1) 44-49 2012 [Refereed]

Misc

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Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity.

OHNO Shigeo

447(17) 2007

Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice.

OHNO Shigeo

Am J Pathol 171(6) 2007

aPKC enables development of zonula adherens by antagonizing centripetal contraction of the circumferential actomyosin cables.

OHNO Shigeo

J Cell Sci 121(15) 2481-2492 2008

The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors.

OHNO Shigeo

39(6) 2008

Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation.

OHNO Shigeo

Dev Cell 14(2) 205-215 2008

Conference Activities & Talks

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A novel signaling pathway by which PAR-aPKC system regulates cell-substate interaction.

2007

The SMG-1:SMG-8:p60 Complex Regulated Phosphorylation Of Upf1 Is Required For The Dissociation Of eRFs From mRNA Surveillance Complex During Nonsense-mediated mRNA decay.

2007

上皮の組織維持・形成と癌化におけるPAR-aPKC系の役割

2007

Defective cell polarity in kidney podocytes causes severe glomerular disease.

Cell Polarity2007 - International Symposium on Cell Polarity System and Future Medicine 2007

Polarity protein PAR-1b regulates extracellular laminin organization through regulation of the utrophin-dystroglycan complex.

Cell Polarity2007 - International Symposium on Cell Polarity System and Future Medicine 2007

Association Memberships

THE JAPANESE CANCER ASSOCIATION(1254) , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN(2478) , The Japanease Biochemical Society(14)

Research Grants & Projects

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Regulation of Cell Polarity as an output of Cell Signaling

Grant-in-Aid for Scientific Research

Project Year: 1991

For the understanding of cellular and molecular bases of diseases such as cancer, we must know the basic mechanisms that control stem and progenitor cells of animal tissues. Among such mechanisms, we focus on the regulatory mechanisms of cell morp...