奥田研爾 (Kenji Okuda) - マイポータル - researchmap

基本情報

学位: 医学博士(横浜市立大学)

J-GLOBAL ID: 200901040404896113
researchmap会員ID: 1000054088

外部リンク: http://www-user.yokohama-cu.ac.jp/~saikin/

研究キーワード

6

研究分野

3

経歴

6

学歴

4

委員歴

3

受賞

3

MISC

118

Xin, K.-Q., N. Jounai, K. Someya, K. Honma, H. Mizuguchi, T. Hayakawa, K. Hamajima, S. Saha, F. Takeshita, K. Okuda, M. Honda, D. M. Klinman, and K.Okuda. Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fi・・・

J Immunol. 2004年
Tanaka, S. I., T. Yamakawa, M. Kimura, I. Aoki, J. Kamei, K. Okuda, and C. Mobbs. Daily nasal inoculation with the insulin gene ameliorates diabetes in mice.

Diabetes Res Clin Pract. 63:1-9 2004年
Takenouchi, H., N. Kiyokawa, T. Taguchi, J. Matsui, Y. U. Katagiri, H. Okita, K. Okuda, and J. Fujimoto. Shiga toxin binding to globotriaosyl ceramide induces intracellular signals that mediate cytoskeleton remodeling in human renal carcinoma-derived ・・・

J Cell Sci 117:3911-3922 2004年
Someya, K., Xin K.-Q., K. Matsuo, K. Okuda, N. Yamamoto, and M. Honda. A consecutive prime-boost vaccination of mice with simian immunodeficiency virus (SIV) gag/pol DNA and recombinant vaccinia virus DIs elicits effective anti-SIV immunity.

J Virol 78:9842-9853 2004年
Sirivichayakul, S., T. Tirawatnapong, K. Ruxrungtham, R. Oelrichs, S. L. Lorenzen, K.-Q. Xin, K. Okuda, and P. Phanuphak. Construction and immunogenicity study of a 297-bp humanized HIV V3 DNA of an approximated last common ancestor in mice.

Asian Pac J Allergy Immunol. 22:49-60 2004年
Shinoda, K., K.-Q. Xin, i. N. Johnai, Kojima. Y., Y. Tamura, E. Okada, S. Kawamoto, K. Okuda, D. Klinman, and K. Okuda. Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice.

Vaccine 22:3676-3690 2004年
Sasaki, S., F. Takeshita, T. Oikawa, Y. Kojima, K.-Q. Xin, K. Okuda, and N. Ishii. Improvement of DNA vaccine immunogenicity by a dual antigen expression system.

Biochem Biophys Res Commun 315:38-43 2004年
Genetic immunization with multiple HIV-1 genes provides protection against HIV-1/MuLV pseudovirus challenge in vivo

J Hinkula, E Rollman, P Lundholm, R Benthin, K Okuda, B Wahren

CELLS TISSUES ORGANS 177(3) 169-184 2004年
Hamajima, K., Kojima, Y., Matsui, K., Toda, Y., Jounai, N., Ozaki, T., Xin, K.-Q., Strong, P. and Okuda, K., Chitin micro-particles (CMP) is a useful adjuvant for inducing viral specific immunity when delivered intranasally with an HIV-DNA vaccine.

Viral Immunol 16(4), 541-547 2003年
Jounai, N., Okuda, K., Kojima, Y., Toda, Y., Hamajima, K., Ohba, K., Klinman, D. and Xin, K.-Q., Contribution of the rev gene to the immunogenicity of DNA vaccines targetting the envelope glycoprotein of HIV.

J Gene Med 5:609-617 2003年
Xin, K.-Q., Ooki, T., Jounai, N., Mizukami, H., Hamajima, K., Kojima, y., Ohba, K., Toda, Y., Hirai, S., Klinman, D. M., Ozawa, K. and Okuda, K., A DNA vaccine containing inverted terminal repeats from adeno-associated virus increases immunity to HIV.

J Gene Med 5: 438-445 2003年
Xin, K.-Q., Hoshino, Y., Toda, Y., Igimi, S., Kojima, Y., Jounai, N., Ohba, K., Kushiro, A., Kiwaki, M., Hamajima, K., Klinman, D. and Okuda, K., Immunogenicity protective efficacy if orally administered recombinant Lactococcus Lactis expressing surfac・・・

Blood 102: 223-228 2003年
Sasaki, S., Takeshita, F., Xin, K.-Q., Ishii, N., Okuda, K., Adjuvant formulations and delivery systems for DNA vaccines,

Methods 31: 243-254 2003年
Yamakawa, T., S. Tanaka, J. Kamei, K. Kadonosono, and K. Okuda. Pitavastatin inhibits vascular smooth muscle cell proliferation by inactivating extracellular signal-regulated kinases 1/2.

J Atheroscler Thromb 10:37-42 2003年
Yamakawa, T., S. Tanaka, J. Kamei, K. Kadonosono, and K. Okuda. Phosphatidylinositol 3-kinase in angiotensin II-induced hypertrophy of vascular smooth muscle cells.

Eur J Pharmacol 478:39-46 2003年
Taniya, T., J. Mitobe, S. Nakayama, M. Qi, K. Okuda, and H. Watanabe. Determination of the InvE binding site required for expression of IpaB of the Shigella sonnei virulence plasmid: Involvement of a ParB BoxA-like sequence.

J Bacteriol 185:5158-5165 2003年
Kawamoto, S., T. Sonoda, C. Mochizuki, T. Yamashita, K. Watanabe, Y. Miyagi, and K. Okuda. Glutamate receptor 2-mediated signal transduction through Delphilin: analysis by Biacore and a yeast two-hybrid system.

In Biacore Journal 3, 12-14 2003年
Xin, K.-Q., Sasaki, S., Kojima, Y., Jounai, N., Kumamoto, Y., Hashimoto, K., Shinoda, K., Hamajima, K. and Okuda, K., Detection of progeny immune responses after intravenous administration of DNA vaccine to pregnant mice.

Biol Proced Online 3: 91-101 2002年
Senuma, A., Hagiwara, E., Nagahama, K., Okuda, K., Nakamura, M., Fukumoto, N., Shirai, A., Tani, K. and Ishigatsubo, Y., Therapeutic effect of CpG motifs on the development of chronic graft-versus-host disease in mice.

CYTOKINE 20: 23-29 2002年
Kobayashi, N., Koshino, T., Uesugi, M., Yokoo, N., Xin, K.-Q., Okuda, K., Mizukami, H., Ozawa, K. and Saito, T., Gene marking in adeno-associated virus vector infected periosteum derived cells for cartilage repair.

J Rheumatol 2002. 29: 2176-2180. 29: 2176-2180 2002年

もっとみる

書籍等出版物

3

Kawamoto S, Hattori S, Uchino S, Mishina M, Okuda K (1999): Expression of NMDA receptor channel subunit proteins using baculovirus and herpesvirus vectors,

In M. Li (Ed.): Methods in Molecular Biology "NMDA Receptor Protocols", Humana Press Inc., Totowa, NJ. 1999年
Sasaki S, Okuda K (1999): The use of conventional immunologic adjuvants in DNA vaccine preparations,

In D. B. a. W. Lowrie, R. G. (Ed.): Methods in Molecular Medicine "DNA Vaccines: Methods and Protocols", Humana press, Totowa, NJ. 1999年
Cytokine and costimulatory factor-encoding plasmids as adjuvants for DNA vaccination, In D. B. a. W. Lowrie, R. G. (Ed.): Methods in Molecular Medicine "DNA Vaccines: Methods and Protocols"

Humana press, Totowa, NJ. 1999年

所属学協会

11

Works(作品等)

1

アルツハイマー病治療薬の投索研究

2002年

共同研究・競争的資金等の研究課題

7

アルツハイマー病の免疫学的療法

2001年 - 2003年
エイズワクチンの研究

特殊法人等における新たな基礎研究推進制度 2001年 - 2003年
脳のグルタミン酸レセプター

受託研究
緑膿菌の分子遺伝学
Analysis of glutamate receptor
Molecular genetic aproches of ┣DBP. (/)-┫DB ┣DBaeruginosa(/)-┫DB
Analysis of AIDS vaccine development

産業財産権

4